Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1970 Dec;2(6):716–722. doi: 10.1128/iai.2.6.716-722.1970

Seroepidemiological and Ecological Studies of the Adenovirus-Associated Satellite Viruses

Wade P Parks a,1, D Wark Boucher a, Joseph L Melnick a, Larry H Taber a, Martha D Yow a
PMCID: PMC416080  PMID: 16557905

Abstract

The seroepidemiology of the defective adenovirus-associated satellite viruses was studied by use of a neutralization test that has been shown to be much more sensitive than the complement-fixation (CF) test. Less than 25% of the subjects in any age group were positive for any type of satellite virus CF antibody. The neutralization test revealed serological evidence of satellite infection in almost 80% of the subjects in some age groups. Studies of geometric mean antibody titers by neutralization showed that antibody against type 1 and the type 2-3 complex reached peak levels at 2 to 3 years of age; antibody against types 2 and 3 reached mean titers of 500 to 800, whereas mean antibody levels of only 200 were found for type 1. Type 4 antibodies were rarely noted in human sera. In a companion study in monkeys, monospecific responses to types 1 and 4 were found only in rhesus and green monkey sera, respectively. These data suggest that the type 2-3 complex may be the only naturally occurring satellite serotype which infects man and that antibodies noted against types 1 and 4 may be the result of cross-reactions. No satellite viruses were isolated from throat or rectal swabs of 100 children between 6 months and 3 years of age. However, the patterns of adenovirus and enterovirus isolations from these specimens were typical of previous studies in this laboratory.

Full text

PDF
716

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ATCHISON R. W., CASTO B. C., HAMMON W. M. ADENOVIRUS-ASSOCIATED DEFECTIVE VIRUS PARTICLES. Science. 1965 Aug 13;149(3685):754–756. doi: 10.1126/science.149.3685.754. [DOI] [PubMed] [Google Scholar]
  2. Blacklow N. R., Hoggan M. D., Kapikian A. Z., Austin J. B., Rowe W. P. Epidemiology of adenovirus-associated virus infection in a nursery population. Am J Epidemiol. 1968 Nov;88(3):368–378. doi: 10.1093/oxfordjournals.aje.a120897. [DOI] [PubMed] [Google Scholar]
  3. Blacklow N. R., Hoggan M. D., Rowe W. P. Isolation of adenovirus-associated viruses from man. Proc Natl Acad Sci U S A. 1967 Oct;58(4):1410–1415. doi: 10.1073/pnas.58.4.1410. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Blacklow N. R., Hoggan M. D., Rowe W. P. Serologic evidence for human infection with adenovirus-associated viruses. J Natl Cancer Inst. 1968 Feb;40(2):319–327. [PubMed] [Google Scholar]
  5. Boucher D. W., Parks W. P., Melnick J. L. A sensitive neutralization test for the adeno-associated satellite viruses. J Immunol. 1970 Mar;104(3):555–559. [PubMed] [Google Scholar]
  6. Boucher D. W., Parks W. P., Melnick J. L. Failure of a replicating adenovirus to enhance adeno-associated satellite virus replication. Virology. 1969 Dec;39(4):932–934. doi: 10.1016/0042-6822(69)90031-2. [DOI] [PubMed] [Google Scholar]
  7. Fox J. P., Brandt C. D., Wassermann F. E., Hall C. E., Spigland I., Kogon A., Elveback L. R. The virus watch program: a continuing surveillance of viral infections in metropolitan New York families. VI. Observations of adenovirus infections: virus excretion patterns, antibody response, efficiency of surveillance, patterns of infections, and relation to illness. Am J Epidemiol. 1969 Jan;89(1):25–50. doi: 10.1093/oxfordjournals.aje.a120913. [DOI] [PubMed] [Google Scholar]
  8. GOLDBLUM N., MELNICK J. L. Complement-fixing antibodies to type 2 (Lansing) poliomyelitis virus in a normal population of a subtropical area. J Exp Med. 1952 Aug;96(2):175–185. doi: 10.1084/jem.96.2.175. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hoggan M. D., Blacklow N. R., Rowe W. P. Studies of small DNA viruses found in various adenovirus preparations: physical, biological, and immunological characteristics. Proc Natl Acad Sci U S A. 1966 Jun;55(6):1467–1474. doi: 10.1073/pnas.55.6.1467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. MELNICK J. L., PARKS W. P. EVALUATION OF COMMUNITY VACCINATION AGAINST POLIOMYELITIS IN HOUSTON, TEXAS, 1962. Am J Hyg. 1964 Sep;80:157–174. doi: 10.1093/oxfordjournals.aje.a120465. [DOI] [PubMed] [Google Scholar]
  11. Melnick J. L., Burkhardt M., Taber L. H., Erckman P. N. Developing gap in immunity to poliomyelitis in an urban area. JAMA. 1969 Aug 25;209(8):1181–1185. [PubMed] [Google Scholar]
  12. Melnick J. L., Mayor H. D., Smith K. O., Rapp F. Association of 20-Millimicron Particles with Adenoviruses. J Bacteriol. 1965 Jul;90(1):271–274. doi: 10.1128/jb.90.1.271-274.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. PHILLIPS C. A., MELNICK J. L. COMMUNITY INFECTION WITH ST. LOUIS ENCEPHALITIS VIRUS. SEROLOGIC STUDY OF THE 1964 EPIDEMIC IN HOUSTON. JAMA. 1965 Jul 19;193:207–211. doi: 10.1001/jama.1965.03090030029006. [DOI] [PubMed] [Google Scholar]
  14. Parks W. P., Melnick J. L., Queiroga L. T., Khan H. A. Studies of infantile diarrhea in Karachi, Pakistan. I. Collection, virus isolation and typing of viruses. Am J Epidemiol. 1966 Sep;84(2):382–395. doi: 10.1093/oxfordjournals.aje.a120651. [DOI] [PubMed] [Google Scholar]
  15. Parks W. P., Melnick J. L., Rongey R., Mayor H. D. Physical assay and growth cycle studies of a defective adeno-satellite virus. J Virol. 1967 Feb;1(1):171–180. doi: 10.1128/jvi.1.1.171-180.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Porter D. D., Wimberly I., Benyesh-Melnick M. Prevalence of antibodies to EB virus and other herpesviruses. JAMA. 1969 Jun 2;208(9):1675–1679. [PubMed] [Google Scholar]
  17. Rapoza N. P., Atchinson R. W. Association of AAV-1 with simian adenoviruses. Nature. 1967 Sep 9;215(5106):1186–1187. doi: 10.1038/2151186a0. [DOI] [PubMed] [Google Scholar]
  18. Rawls W. E., Tompkins W. A., Melnick J. L. The association of herpesvirus type 2 and carcinoma of the uterine cervix. Am J Epidemiol. 1969 May;89(5):547–554. doi: 10.1093/oxfordjournals.aje.a120967. [DOI] [PubMed] [Google Scholar]
  19. Smith K. O., Gehle W. D., Thiel J. F. Properties of a small virus associated with adenovirus type 4. J Immunol. 1966 Dec;97(6):754–766. [PubMed] [Google Scholar]
  20. Yow M. D., Melnick J. L., Blattner R. J., Stephenson W. B., Robinson N. M., Burkhardt M. A. The association of viruses and bacteria with infantile diarrhea. Am J Epidemiol. 1970 Jul;92(1):33–39. doi: 10.1093/oxfordjournals.aje.a121177. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES