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. 1970 Dec;2(6):731–734. doi: 10.1128/iai.2.6.731-734.1970

Interferon Induction by the Psittacosis Agent in Guinea Pig Leukocyte Cultures

Edmund H Kozikowski 1, Nicholas Hahon 1
PMCID: PMC416083  PMID: 16557908

Abstract

High titers of interferon were induced by the psittacosis agent in guinea pig leukocyte cultures. Optimal yields of interferon were produced from freshly prepared guinea pig leukocyte cultures containing 4 × 106 cells per ml inoculated with a psittacosis/cell multiplicity of 1.0 and incubated at 35 C for 24 hr. Leukocytes obtained from 2- to 4-month-old guinea pigs produced 20 times more interferon than leukocytes from 3- to 4-week-old animals. The biological activity of interferon and the kinetics of its production from psittacosis-infected guinea pig leukocyte cultures were similar to those reported for virus-induced leukocyte interferons.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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