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. 1970 Dec;2(6):810–814. doi: 10.1128/iai.2.6.810-814.1970

Effect of Antimacrophage Serum on Dermal Tuberculin Sensitivity and Allergic Pulmonary Granuloma Formation in Rabbits

V L Moore 1, Q N Myrvik 1
PMCID: PMC416095  PMID: 16557920

Abstract

Anti-rabbit alveolar macrophage goat serum (AMS), adsorbed of hemolysins and hemagglutinins, exhibited complement-dependent cytotoxicity for the following rabbit target cells: alveolar macrophages, thymocytes, and kidney (RK-13) cells. The intravenous injection of AMS, sufficient to reduce markedly the dermal tuberculin reaction in BCG-sensitized rabbits, did not suppress the development of BCG-induced chronic and accelerated pulmonary granulomas. These observations are discussed in relation to delayed sensitivity, allergic granuloma formation, and cell-associated immunity.

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Selected References

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