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The virulence kinetics of the G217B strain is delayed in vitro. Macrophage survival was measured as the reduction in macrophage DNA remaining after incubation of macrophages with Histoplasma yeast cells. Macrophage DNA remaining at 3, 6, and 9 days postinoculation was normalized to that in uninfected populations of macrophages. Data represent results of two independent assays. Error bars represent the standard errors of the means.
