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. 1971 Mar;3(3):405–410. doi: 10.1128/iai.3.3.405-410.1971

Bactericidal Effect and Serological Response of Blood and Secretions in Bovine Vibriosis

S P Carrier 1, T T Kramer 1
PMCID: PMC416165  PMID: 16557987

Abstract

Udder infection of vaccinated heifers with Vibrio fetus var. venerealis led to an early and severe reaction consisting of local swelling, hyperthermia, and increased blood leukocyte counts. This reaction was absent or less pronounced in heifers not previously vaccinated. This was interpreted as an immediate hypersensitivity reaction elicited in the vaccinated heifers. Specific antibodies were found in udder exudate from vaccinated heifers. Immune serum and udder exudate were moderately bactericidal and had a strong immunosuppressive and opsonophagocytic effect in rabbits. Immune cervicovaginal mucus was neither bactericidal nor opsonophagocytic or immunosuppressive. This would suggest that antibodies found in cervicovaginal mucus are not protective. It appeared that the immediate hypersensitivity observed and the subsequent transfer of antibodies from serum to udder exudate would provide by analogy a possible explanation of the mechanisms of immunity to bovine vibriosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AUST J. B., AUSMAN R. K. End results of isolated perfusion for squamous cell carcinoma and adenocarcinoma. Cancer Chemother Rep. 1960 Dec;10:89–91. [PubMed] [Google Scholar]
  2. Clark B. L., Dufty J. H., Monsbourgh M. J. Experimental Vibrio fetus (venerealis) infection in heifers. The immunising properties of killed organisms injected subcutaneously. Aust Vet J. 1968 Mar;44(3):110–114. doi: 10.1111/j.1751-0813.1968.tb09034.x. [DOI] [PubMed] [Google Scholar]
  3. Clark B. L., Newsam I. D., Monsbourgh M. J., Dufty J. H. Experimental vibrio fetus infection in cows. Studies on the immunising properties of living organisms injected subcutaneously. Aust Vet J. 1967 Sep;43(9):341–345. doi: 10.1111/j.1751-0813.1967.tb04876.x. [DOI] [PubMed] [Google Scholar]
  4. DIXON F. J., WEIGLE W. O., VAZQUEZ J. J. Metabolism and mammary secretion of serum proteins in the cow. Lab Invest. 1961 Mar-Apr;10:216–237. [PubMed] [Google Scholar]
  5. FELDMAN J. D. Fine structure of the cow's udder during gestation and lactation. Lab Invest. 1961 Mar-Apr;10:238–255. [PubMed] [Google Scholar]
  6. FRANK A. H., SHALKOP W. T., BRYNER J. H., O'BERRY P. A. Cellular changes in the endometrium of Vibrio fetus-infected and noninfected heifers. Am J Vet Res. 1962 Nov;23:1213–1216. [PubMed] [Google Scholar]
  7. Frank A. H., Bryner J. H., O'Berry P. A. The effect of Vibrio fetus vaccination on the breeding efficiency of cows bred to vibrio fetus-infected bulls. Am J Vet Res. 1967 Sep;28(126):1237–1242. [PubMed] [Google Scholar]
  8. HOERLEIN A. B., CARROLL E. J., KRAMER T., BECKENHAUER W. H. BOVINE VIBRIOSIS IMMUNIZATION. J Am Vet Med Assoc. 1965 Apr 15;146:828–835. [PubMed] [Google Scholar]
  9. HOERLEIN A. B., KRAMER T. ARTIFICIAL STIMULATION OF RESISTANCE TO BOVINE VIBRIOSIS. Am J Vet Res. 1963 Sep;24:951–955. [PubMed] [Google Scholar]
  10. HOERLEIN A. B., KRAMER T. ARTIFICIAL STIMULATION OF RESISTANCE TO BOVINE VIBRIOSIS: USE OF BACTERINS. Am J Vet Res. 1964 Mar;25:371–373. [PubMed] [Google Scholar]
  11. HUGHES D. E. A study of the diagnosis of bovine vibriosis with special reference to the detection of agglutinins in the vaginal secretions. Cornell Vet. 1953 Jul;43(3):431–444. [PubMed] [Google Scholar]
  12. Kramer T., Hoerlein A. B. Serologic response of heifers vaccinated and exposed to vibriosis. Am J Vet Res. 1969 Jul;30(7):1089–1098. [PubMed] [Google Scholar]
  13. Larson K., Ringen L. Serologic analysis of bovine vibriosis. Am J Vet Res. 1967 Sep;28(126):1231–1235. [PubMed] [Google Scholar]
  14. MUSCHEL L. H. Serum bactericidal actions. Ann N Y Acad Sci. 1960 Nov 21;88:1265–1272. doi: 10.1111/j.1749-6632.1960.tb20117.x. [DOI] [PubMed] [Google Scholar]
  15. Mitchell D. Some effects of experimental Vibrio fetus (venerealis) infection on cattle inoculated with a commercial bacterin. Can J Comp Med. 1968 Jul;32(3):474–479. [PMC free article] [PubMed] [Google Scholar]
  16. Te Punga W. A., Boyes B. W., Young J. S., Wallace N. M. Vibriosis in cattle. 4. Further studies on control by vaccination. N Z Vet J. 1964 Oct;12(5):121–122. doi: 10.1080/00480169.1964.33568. [DOI] [PubMed] [Google Scholar]
  17. Te Punga W. A., Boyes B. W., Young J. S., Wallace N. M. Vibriosis in cattle. 4. Further studies on control by vaccination. N Z Vet J. 1964 Oct;12(5):121–122. doi: 10.1080/00480169.1964.33568. [DOI] [PubMed] [Google Scholar]
  18. Tomasi T. B., Jr, Bienenstock J. Secretory immunoglobulins. Adv Immunol. 1968;9:1–96. doi: 10.1016/s0065-2776(08)60441-1. [DOI] [PubMed] [Google Scholar]

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