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. 1971 Mar;3(3):496–497. doi: 10.1128/iai.3.3.496-497.1971

Protection of Mycobacterium smegmatis from Ethambutol and Streptomycin Inhibition by MgSO4 and Polyamines

William H Beggs 1, Nancy E Williams 1
PMCID: PMC416180  PMID: 16558002

Abstract

Polyamines protected Mycobacterium smegmatis from ethambutol inhibition but not from streptomycin inhibition, whereas MgSO4 neutralized growth inhibition by both drugs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRAGG P. D., POLGLASE W. J. ACTION OF DIHYDROSTREPTOMYCIN AND ANTAGONISM BY CATIONS. J Bacteriol. 1963 Mar;85:590–594. doi: 10.1128/jb.85.3.590-594.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beggs W. H., Jenne J. W. Mechanism for the pyridoxal neutralization of isoniazid action of Mycobacterium tuberculosis. J Bacteriol. 1967 Oct;94(4):793–797. doi: 10.1128/jb.94.4.793-797.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Donovick R., Bayan A. P., Canales P., Pansy F. The Influence of Certain Substances on the Activity of Streptomycin: III. Differential Effects of Various Electrolytes on the Action of Streptomycin. J Bacteriol. 1948 Jul;56(1):125–137. [PMC free article] [PubMed] [Google Scholar]
  4. FORBES M., KUCK N. A., PEETS E. A. EFFECT OF ETHAMBUTOL ON NUCLEIC ACID METABOLISM IN MYCOBACTERIUM SMEGMATIS AND ITS REVERSAL BY POLYAMINES AND DIVALENT CATIONS. J Bacteriol. 1965 May;89:1299–1305. doi: 10.1128/jb.89.5.1299-1305.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FORBES M., KUCK N. A., PEETS E. A. Mode of action of ethambutol. J Bacteriol. 1962 Nov;84:1099–1103. doi: 10.1128/jb.84.5.1099-1103.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. MAGER J., BENEDICT M., ARTMAN M. A common site of action of polyamines and streptomycin. Biochim Biophys Acta. 1962 Jul 30;62:202–204. doi: 10.1016/0006-3002(62)90519-x. [DOI] [PubMed] [Google Scholar]
  7. PLOTZ P. H., DUBIN D. T., DAVIS B. D. Influence of salts on the uptake of streptomycin by Escherichia coli. Nature. 1961 Sep 23;191:1324–1325. doi: 10.1038/1911324a0. [DOI] [PubMed] [Google Scholar]
  8. PRAMER D. Absorption of antibiotics by plant cells. II. Streptomycin. Arch Biochem Biophys. 1956 Jun;62(2):265–273. doi: 10.1016/0003-9861(56)90124-2. [DOI] [PubMed] [Google Scholar]

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