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. 1971 Apr;3(4):516–520. doi: 10.1128/iai.3.4.516-520.1971

Effect of Separate and Combined Injections of Poly rI: Poly rC and Endotoxin on Reticulo-endothelial Activity, Interferon, and Antibody Production in the Mouse

Thomas J Chester 1, Erik de Clercq 1, Thomas C Merigan 1
PMCID: PMC416187  PMID: 16558008

Abstract

The effect of repeated stimulation on both the interferon and antibody systems and on reticuloendothelial activity was studied by injection of endotoxin 2 days before injection of (poly rI):(poly rC). A single injection of endotoxin or (poly rI):(poly rC) increased or decreased the response in each system depending on the time of administration. If the injection of (poly rI):(poly rC) was preceded by an injection of endotoxin 2 days before, its activity was markedly reduced in all of the three systems studied. Although different doses of endotoxin were required to induce a state of hyporeactivity or tolerance to the effects of (poly rI):(poly rC) in either system, it is possible that a common mechanism underlies the hyporeactivity in all systems.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIOZZI G., BENACERRAF B., HALPERN B. N. Quantitative study of the granulopectic activity of the reticulo-endothelial system. II. A study of the kinetics of the R. E. S. in relation to the dose of carbon injected; relationship between the weight of the organs and their activity. Br J Exp Pathol. 1953 Aug;34(4):441–457. [PMC free article] [PubMed] [Google Scholar]
  2. Braun W., Nakano M. Antibody formation: stimulation by polyadenylic and polycytidylic acids. Science. 1967 Aug 18;157(3790):819–821. doi: 10.1126/science.157.3790.819. [DOI] [PubMed] [Google Scholar]
  3. Braun W., Regelson W., Yajima Y., Ishizuka M. Stimulation of antibody formation by pyran copolymer. Proc Soc Exp Biol Med. 1970 Jan;133(1):171–175. doi: 10.3181/00379727-133-34433. [DOI] [PubMed] [Google Scholar]
  4. Braun W., Yajima Y., Ishizuka M. Synthetic polynucleotides as restorers of normal antibody-forming capacities in aged mice. J Reticuloendothel Soc. 1970 Mar;7(3):418–424. [PubMed] [Google Scholar]
  5. DICARLO F. J., HAYNES L. J., PHILLIPS G. E. Effect of Mycobacterium phlei upon reticuloendothelial system of mice of different ages. Proc Soc Exp Biol Med. 1963 Mar;112:651–654. doi: 10.3181/00379727-112-28129. [DOI] [PubMed] [Google Scholar]
  6. DILUZIO N. R., WOOLES W. R. DEPRESSION OF PHAGOCYTIC ACTIVITY AND IMMUNE RESPONSE BY METHYL PALMITATE. Am J Physiol. 1964 May;206:939–943. doi: 10.1152/ajplegacy.1964.206.5.939. [DOI] [PubMed] [Google Scholar]
  7. De Clercq E., Merigan T. C. Current concepts of interferon and interferon induction. Annu Rev Med. 1970;21:17–46. doi: 10.1146/annurev.me.21.020170.000313. [DOI] [PubMed] [Google Scholar]
  8. De Clercq E., Merigan T. C. Induction of interferon by nonviral agents. Arch Intern Med. 1970 Jul;126(1):94–108. doi: 10.1001/archinte.126.1.94. [DOI] [PubMed] [Google Scholar]
  9. De Clercq E., Nuwer M. R., Merigan T. C. The role of interferon in the protective effect of a synthetic double-stranded polyribonucleotide against intranasal vesicular stomatitis virus challenge in mice. J Clin Invest. 1970 Aug;49(8):1565–1577. doi: 10.1172/JCI106374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. MacGregor R. R., Sheagren J. N., Wolff S. M. Endotoxin-induced modification of Plasmodium berghei infection in mice. J Immunol. 1969 Jan;102(1):131–139. [PubMed] [Google Scholar]
  11. Merigan T. C., Finkelstein M. S. Interferon-stimulating and in vivo antiviral effects of various synthetic anionic polymers. Virology. 1968 Jul;35(3):363–374. doi: 10.1016/0042-6822(68)90215-8. [DOI] [PubMed] [Google Scholar]
  12. Mishell R. I., Dutton R. W. Immunization of dissociated spleen cell cultures from normal mice. J Exp Med. 1967 Sep 1;126(3):423–442. doi: 10.1084/jem.126.3.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Munson A. E., Regelson W., Lawrence W., Jr, Wooles W. R. Biphasic response of the reticuloendothelial system (RES) induced by pyran copolymer. J Reticuloendothel Soc. 1970 Mar;7(3):375–385. [PubMed] [Google Scholar]
  14. Turner W., Chan S. P., Chirigos M. A. Stimulation of humoral and cellular antibody formation in mice by poly Ir:Cr. Proc Soc Exp Biol Med. 1970 Jan;133(1):334–338. doi: 10.3181/00379727-133-34469. [DOI] [PubMed] [Google Scholar]
  15. Winchurch R., Braun W. Antibody formation: premature initiation by endotoxin or synthetic polynucleotides in newborn mice. Nature. 1969 Aug 23;223(5208):843–844. doi: 10.1038/223843a0. [DOI] [PubMed] [Google Scholar]
  16. Woodhour A. F., Friedman A., Tytell A. A., Hilleman M. R. Hyperpotentiation by synthetic double-stranded RNA of antibody responses to influenza virus vaccine in adjuvant 65. Proc Soc Exp Biol Med. 1969 Jul;131(3):809–817. doi: 10.3181/00379727-131-33983. [DOI] [PubMed] [Google Scholar]
  17. Youngner J. S., Hallum J. V. Interferon production in mice by double-stranded synthetic polynucleotides: induction or release? Virology. 1968 May;35(1):177–179. doi: 10.1016/0042-6822(68)90320-6. [DOI] [PubMed] [Google Scholar]
  18. Youngner J. S., Stinebring W. R. Interferon appearance stimulated by endotoxin, bacteria, or viruses in mice pre-treated with Escherichia coli endotoxin or infected with Mycobacterium tuberculosis. Nature. 1965 Oct 30;208(5009):456–458. doi: 10.1038/208456a0. [DOI] [PubMed] [Google Scholar]

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