Skip to main content
Infection and Immunity logoLink to Infection and Immunity
. 1971 May;3(5):688–693. doi: 10.1128/iai.3.5.688-693.1971

Effect of Ethanol on the Clearance of Airborne Pneumococci and the Rate of Pneumococcal Transformations in the Lung

Fran Auerbach-Rubin a,1, Elena Ottolenghi-Nightingale a,2
PMCID: PMC416217  PMID: 16558037

Abstract

The rate of clearance of pneumococci from the lungs of mice infected by aerosols was found to vary inversely with the virulence of the pneumococci. Treatment of of the mice with ethanol delayed the clearance and increased the rate of pneumococcal transformations in vivo.

Full text

PDF
688

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brayton R. G., Stokes P. E., Schwartz M. S., Louria D. B. Effect of alcohol and various diseases on leukocyte mobilization, phagocytosis and intracellular bacterial killing. N Engl J Med. 1970 Jan 15;282(3):123–128. doi: 10.1056/NEJM197001152820303. [DOI] [PubMed] [Google Scholar]
  2. Conant J. E., Sawyer W. D. Transformation during mixed pneumococcal infection of mice. J Bacteriol. 1967 Jun;93(6):1869–1875. doi: 10.1128/jb.93.6.1869-1875.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. GREEN G. M., KASS E. H. FACTORS INFLUENCING THE CLEARANCE OF BACTERIA BY THE LUNG. J Clin Invest. 1964 Apr;43:769–776. doi: 10.1172/JCI104961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Green G. M., Kass E. H. The influence of bacterial species on pulmonary resistance to infection in mice subjected to hypoxia, cold stress, and ethanolic intoxication. Br J Exp Pathol. 1965 Jun;46(3):360–366. [PMC free article] [PubMed] [Google Scholar]
  5. Green G. M. Patterns of bacterial clearance in murine influenza. Antimicrob Agents Chemother (Bethesda) 1965;5:26–29. [PubMed] [Google Scholar]
  6. Guarneri J. J., Laurenzi G. A. Effect of alcohol on the mobilization of alveolar macrophages. J Lab Clin Med. 1968 Jul;72(1):40–51. [PubMed] [Google Scholar]
  7. HOTCHKISS R. D. Transfer of penicillin resistance in pneumococci by the desoxyribonucleate derived from resistant cultures. Cold Spring Harb Symp Quant Biol. 1951;16:457–461. doi: 10.1101/sqb.1951.016.01.032. [DOI] [PubMed] [Google Scholar]
  8. Klein J. O., Green G. M., Tilles J. G., Kass E. H., Finland M. Effect of intranasal reovirus infection on antibacterial activity of mouse lung. J Infect Dis. 1969 Jan;119(1):43–50. doi: 10.1093/infdis/119.1.43. [DOI] [PubMed] [Google Scholar]
  9. LAURENZI G. A., GUARNERI J. J., ENDRIGA R. B. IMPORTANT DETERMINANTS IN PULMONARY RESISTANCE TO BACTERIAL INFECTION. Med Thorac. 1965;22:48–59. [PubMed] [Google Scholar]
  10. Laurenzi G. A., Guarneri J. J. Effects of bacteria and viruses on ciliated epithelium. A study of the mechanisms of pulmonary resistance to infection: the relationship of bacterial clearance to ciliary and alveolar macrophage function. Am Rev Respir Dis. 1966 Mar;93(3 Suppl):134–141. doi: 10.1164/arrd.1966.93.3P2.134. [DOI] [PubMed] [Google Scholar]
  11. OTTOLENGHI E., HOTCHKISS R. D. Appearance of genetic transforming activity in pneumococcal cultures. Science. 1960 Oct 28;132(3435):1257–1258. [PubMed] [Google Scholar]
  12. OTTOLENGHI E., HOTCHKISS R. D. Release of genetic transforming agent from pneumococcal cultures during growth and disintegration. J Exp Med. 1962 Oct 1;116:491–519. doi: 10.1084/jem.116.4.491. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. OTTOLENGHI E., MACLEOD C. M. GENETIC TRANSFORMATION AMONG LIVING PNEUMOCOCCI IN THE MOUSE. Proc Natl Acad Sci U S A. 1963 Sep;50:417–419. doi: 10.1073/pnas.50.3.417. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ottolenghi-Nightingale E. Spontaneously occurring bacterial transformations in mice. J Bacteriol. 1969 Oct;100(1):445–452. doi: 10.1128/jb.100.1.445-452.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. SCHULMAN J. L., KILBOURNE E. D. EXPERIMENTAL TRANSMISSION OF INFLUENZA VIRUS INFECTION IN MICE. I. THE PERIOD OF TRANSMISSIBILITY. J Exp Med. 1963 Aug 1;118:257–266. doi: 10.1084/jem.118.2.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. TOMASZ A., HOTCHKISS R. D. REGULATION OF THE TRANSFORMABILITY OF PHEUMOCOCCAL CULTURES BY MACROMOLECULAR CELL PRODUCTS. Proc Natl Acad Sci U S A. 1964 Mar;51:480–487. doi: 10.1073/pnas.51.3.480. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. VAN METRE T. E., Jr Pneumococcal pneumonia treated with antibiotics; the prognostic significance of certain clinical findings. N Engl J Med. 1954 Dec 23;251(26):1048–1052. doi: 10.1056/NEJM195412232512604. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES