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. 1971 Jun;3(6):715–722. doi: 10.1128/iai.3.6.715-722.1971

Rabbit Arthritis Induced by Cell-Free Extracts of Erysipelothrix

Thomas G White 1,2, Jerry L Puls 1,2,1, Frank K Mirikitani 1,2
PMCID: PMC416227  PMID: 16558044

Abstract

A cell-free crude extract of Erysipelothrix rhusiopathiae injected intravenously in rabbits induced pathological lesions of the synovial tissue similar to the lesions seen in rheumatoid arthritis. Fluorescence techniques utilizing tagged specific antiserum and fluorescent-tagged antigen injected into nonsensitized rabbits demonstrated the localization of antigen exclusively in the synovium. Localized concentration of fluorescence was demonstrated as early as 1 hr after injection, before histological changes were apparent. After 48 hr, the fluorescence was concentrated in focal areas and early pathological changes characterized as “mesenchymal activation” were observed. A consideration of the significant role of exogenous antigen in the sensitivity arthritides is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABRUZZO J. L., CHRISTIAN C. L. The induction of a rheumatoid factor-like substance in rabbits. J Exp Med. 1961 Nov 1;114:791–806. doi: 10.1084/jem.114.5.791. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CHRISTIAN C. L. RHEUMATOID FACTOR PROPERTIES OF HYPERIMMUNE RABBIT SERA. J Exp Med. 1963 Nov 1;118:827–844. doi: 10.1084/jem.118.5.827. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DUMONDE D. C., GLYNN L. E. The production of arthritis in rabbits by an immunological reaction to fibrin. Br J Exp Pathol. 1962 Aug;43:373–383. [PMC free article] [PubMed] [Google Scholar]
  4. KALF G. A., GRECE M. A. THE ANTIGENIC COMPONENTS OF ERYSIPELOTHRIX RHUSIOPATHIAE. 3. PURIFICATION OF B- AND C-ANTIGENS. Arch Biochem Biophys. 1964 Jul;107:141–146. doi: 10.1016/0003-9861(64)90281-4. [DOI] [PubMed] [Google Scholar]
  5. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  6. Rickles N., Zilberstein Z., Kraus S., Arad G., Kaufstein M., Ginsburg I. Persistence of group A streptococci labeled with fluorescein isothiocyanate in inflammatory sites in the heart and muscle of mice and rabbits. Proc Soc Exp Biol Med. 1969 Jun;131(2):525–530. doi: 10.3181/00379727-131-33917. [DOI] [PubMed] [Google Scholar]
  7. Schwab J. H., Cromartie W. J., Ohanian S. H., Craddock J. G. Association of experimental chronic arthritis with the persistence of group A streptococcal cell walls in the articular tissue. J Bacteriol. 1967 Nov;94(5):1728–1735. doi: 10.1128/jb.94.5.1728-1735.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Timoney J. F., Jr, Berman D. T. Erysipelothrix arthritis in swine: bacteriologic and immunopathologic aspects. Am J Vet Res. 1970 Aug;31(8):1411–1421. [PubMed] [Google Scholar]
  9. WAKSMAN B. H., WENNERSTEN C. PASSIVE TRANSFER OF ADJUVANT ARTHRITIS IN RATS WITH LIVING LYMPHOID CELLS OF SENSITIZED DONORS. Int Arch Allergy Appl Immunol. 1963;23:129–139. doi: 10.1159/000229412. [DOI] [PubMed] [Google Scholar]
  10. WHITE T. G., KALF G. F. The antigenic components of Erysipelothrix rhusiopathiae. I. Isolation and serological identification. Arch Biochem Biophys. 1961 Dec;95:458–463. doi: 10.1016/0003-9861(61)90176-x. [DOI] [PubMed] [Google Scholar]
  11. White T. G., Puls J. L. Induction of experimental chronic arthritis in rabbits by cell-free fragments of Erysipelothrix. J Bacteriol. 1969 May;98(2):403–406. doi: 10.1128/jb.98.2.403-406.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]

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