Abstract
A hemagglutinin extracted from the L-phase of Neisseria meningitidis group B directly agglutinated rabbit and rooster erythrocytes but did not react with human, sheep, or guinea pig erythrocytes. Virtually all animal, chicken, and human sera tested showed inhibitory titers. In a significant number of Navy recruits, who became carriers of N. meningitidis, the titer of serum inhibitor began to decline 2 weeks before the bacterial infection was first detected. Titers of this serum inhibitor ranged from 256 to 4,096 in patients with meningitis. The hemagglutinin failed to boost the preexisting titers of serum inhibitor when injected into animals, although roosters showed a minimal but transitory response.
Full text
PDF







Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bohnhoff M., Page M. I. Experimental infection with parent and L-phase variants of Neisseria meningitidis. J Bacteriol. 1968 Jun;95(6):2070–2077. doi: 10.1128/jb.95.6.2070-2077.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COETZEE J. N., PERNET G. Fimbriae and haemagglutinating properties in strains of Proteus. Nature. 1962 Nov 3;196:497–498. doi: 10.1038/196497a0. [DOI] [PubMed] [Google Scholar]
- COLLEE J. G. The nature and properties of the haemagglutinin of Clostridium welchii. J Pathol Bacteriol. 1961 Apr;81:297–312. doi: 10.1002/path.1700810202. [DOI] [PubMed] [Google Scholar]
- Devine L. F., Knowles R. C., Pierce W. E., Peckinpaugh R. O., Hagerman C. R., Lytle R. I. Proposed model for screening antimicrobial agents for potential use in eliminating meningococci from the nasopharynx of healthy carriers. Antimicrob Agents Chemother (Bethesda) 1968;8:307–314. [PubMed] [Google Scholar]
- IVLER D., PRESTON H. M., PORTNOY B. DIRECT HEMAGGLUTINATION BY HEMOPHILUS INFLUENZAE. Proc Soc Exp Biol Med. 1963 Oct;114:232–234. doi: 10.3181/00379727-114-28637. [DOI] [PubMed] [Google Scholar]
- JASINSKA S., WACHNIK Z. [Hemagglutination properties of Listeria monocytogenes strains]. Med Dosw Mikrobiol. 1961;13:43–45. [PubMed] [Google Scholar]
- Mann J. M., Rheins M. S. Hemagglutinating property of Haemophilus aegyptius. Appl Microbiol. 1968 Sep;16(9):1343–1347. doi: 10.1128/am.16.9.1343-1347.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mulczyk M. Hemagglutinating properties of Shigella bacilli. Arch Immunol Ther Exp (Warsz) 1967;15(4):636–639. [PubMed] [Google Scholar]
- NETER E. Bacterial hemagglutination and hemolysis. Bacteriol Rev. 1956 Sep;20(3):166–188. doi: 10.1128/br.20.3.166-188.1956. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RAUNIO V. Haemagglutination caused by pneumococci. Ann Med Exp Biol Fenn. 1959;37:243–250. [PubMed] [Google Scholar]
- SVARTZ N. A haemagglutinating factor experimentally produced with pleomorphous diplococci of the streptococcus agalactiae group; preliminary report. Acta Med Scand. 1960 May 20;167:77–78. doi: 10.1111/j.0954-6820.1960.tb03519.x. [DOI] [PubMed] [Google Scholar]
