Skip to main content
Brain logoLink to Brain
letter
. 2014 Jun 11;137(10):e300. doi: 10.1093/brain/awu145

Music, reward and frontotemporal dementia

Phillip D Fletcher 1, Camilla N Clark 1, Jason D Warren 1,
PMCID: PMC4163029  PMID: 24919970

Sir, The recent study by Perry et al. (2014) draws attention to the important issue of abnormally enhanced reward-seeking by patients with frontotemporal dementia (FTD). This issue presents major challenges for the clinical management of these patients and provides a unique window on the neurobiology of brain network disintegration in a diverse group of neurodegenerative pathologies. While Perry and colleagues emphasize seeking of stimuli with clear biological reward potential (sweet foods, drugs of abuse and sex), abnormal reward-seeking in FTD is not restricted to such stimuli. Indeed, one of the most potent inducers of such behaviour in patients with FTD is a stimulus with no clear biological value: music. Abnormal, intense craving for music (musicophilia) is common in FTD and has a cerebral correlate centred on the mesial temporal lobe (Fletcher et al., 2013).

Both in functional imaging studies of the healthy brain and in neurodegenerative disease (Omar et al., 2011; Salimpoor et al., 2013; Clark et al., 2014), music has been shown to engage striatal and basal forebrain regions overlapping or intimately connected with those demonstrated by Perry et al. (2014), in addition to a distributed network of cortical and limbic structures. Why music should behave as a biologically rewarding stimulus remains unresolved although clues may lie with its capacity to encode emotional mental states (Clark et al., 2014): a cognitive process that is also often catastrophically disrupted in FTD.

We therefore suggest music as a promising candidate model system for addressing some of the key questions for future work raised by the study of Perry and colleagues. In particular, as a universal and widely valued, yet abstract stimulus, music is ideally suited to probe interactions between reward, affective and cortical information processing circuitry (Omar et al., 2011; Salimpoor et al. 2013). This circuitry is inherently vulnerable in FTD. Moreover, a stimulus that can dissect apart the components of such large-scale brain networks may enable hedonic and physiological phenotyping of a range of other neurodegenerative disorders (including Parkinson’s disease) that also cause profound derangements of reward processing.

References

  1. Clark CN, Downey LE, Warren JD. Music biology: all this useful beauty. Curr Biol. 2014;24:R234–7. doi: 10.1016/j.cub.2014.02.013. [DOI] [PubMed] [Google Scholar]
  2. Fletcher PD, Downey LE, Witoonpanich P, Warren JD. The brain basis of musicophilia: evidence from frontotemporal lobar degeneration. Front Psychol. 2013;4:347. doi: 10.3389/fpsyg.2013.00347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Omar R, Henley SM, Bartlett JW, Hailstone JC, Gordon E, Sauter DA, et al. The structural neuroanatomy of music emotion recognition: evidence from frontotemporal lobar degeneration. Neuroimage. 2011;56:1814–21. doi: 10.1016/j.neuroimage.2011.03.002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Perry DC, Sturm VE, Seeley WW, Miller BL, Kramer JH, Rosen HJ. Anatomical correlates of reward-seeking behaviours in behavioural variant frontotemporal dementia. Brain. 2014;137:1621–26. doi: 10.1093/brain/awu075. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Salimpoor VN, van den Bosch I, Kovacevic N, McIntosh AR, Dagher A, Zatorre RJ. Interactions between the nucleus accumbens and auditory cortices predict music reward value. Science. 2013;340:216–9. doi: 10.1126/science.1231059. [DOI] [PubMed] [Google Scholar]

Articles from Brain are provided here courtesy of Oxford University Press

RESOURCES