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. 1971 Oct;4(4):323–330. doi: 10.1128/iai.4.4.323-330.1971

Hemopoietic Colony-Forming Cell Responses in Mice Infected with Ectromelia Virus

T A McNeill 1, M Killen 1
PMCID: PMC416309  PMID: 4343405

Abstract

The responses of in vitro colony-forming cells (granulocyte-macrophage progenitor cells) were studied in the bone marrow, spleen, and blood of mice after intraperitoneal injection of 103 plaque-forming units of ectromelia virus. This study showed that a colony-forming cell response occurred during infection and was accompanied by an increase in the serum level of colony-stimulating factor and, at a later stage, colony-inhibiting factor. Changes in the proportions of colony-forming cells were not due to relative changes in other cell populations. The relationships between colony-forming cell responses and levels of infection were complex, higher levels of infection being associated with good colony-forming cell responses in bone marrow and apparently poor colony-forming cell responses in blood and spleen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BALNER H. Identification of peritoneal macrophages in mouse radiation chimeras. Transplantation. 1963 Apr;1:217–223. doi: 10.1097/00007890-196301020-00009. [DOI] [PubMed] [Google Scholar]
  2. BRIODY B. A. Response of mice to ectromelia and vaccinia viruses. Bacteriol Rev. 1959 Jun;23(2):61–95. doi: 10.1128/br.23.2.61-95.1959. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bradley T. R., Metcalf D. The growth of mouse bone marrow cells in vitro. Aust J Exp Biol Med Sci. 1966 Jun;44(3):287–299. doi: 10.1038/icb.1966.28. [DOI] [PubMed] [Google Scholar]
  4. Bradley T. R., Sumner M. A. Stimulation of mouse bone marrow colony growth in vitro by conditioned medium. Aust J Exp Biol Med Sci. 1968 Oct;46(5):607–618. doi: 10.1038/icb.1968.167. [DOI] [PubMed] [Google Scholar]
  5. FENNER F. Mouse-pox; infectious ectromelia of mice; a review. J Immunol. 1949 Dec;63(4):341–373. [PubMed] [Google Scholar]
  6. Foster R., Jr, Metcalf D., Robinson W. A., Bradley T. R. Bone marrow colony stimulating activity in human sera. Results of two independent surveys in Buffalo and Melbourne. Br J Haematol. 1968 Aug;15(2):147–159. doi: 10.1111/j.1365-2141.1968.tb01524.x. [DOI] [PubMed] [Google Scholar]
  7. Hall B. M. The effects of whole body irradiation on serum colony stimulating factor and in vitro colony-forming cells in the bone marrow. Br J Haematol. 1969 Dec;17(6):553–561. doi: 10.1111/j.1365-2141.1969.tb01406.x. [DOI] [PubMed] [Google Scholar]
  8. Haskill J. S., McNeill T. A., Moore M. A. Density distribution analysis of in vivo and in vitro colony forming cells in bone marrow. J Cell Physiol. 1970 Apr;75(2):167–179. doi: 10.1002/jcp.1040750206. [DOI] [PubMed] [Google Scholar]
  9. Hulliger L., Blazkovec A. A. A simple and efficient method of separating peripheral-blood leucocytes for in-vitro studies. Lancet. 1967 Jun 17;1(7503):1304–1305. doi: 10.1016/s0140-6736(67)91596-6. [DOI] [PubMed] [Google Scholar]
  10. Ichikawa Y., Pluznik D. H., Sachs L. In vitro control of the development of macrophage and granulocyte colonies. Proc Natl Acad Sci U S A. 1966 Aug;56(2):488–495. doi: 10.1073/pnas.56.2.488. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. MIMS C. A. ASPECTS OF THE PATHOGENESIS OF VIRUS DISEASES. Bacteriol Rev. 1964 Mar;28:30–71. doi: 10.1128/br.28.1.30-71.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. McNeill T. A. Antigenic stimulation of bone marrow colony forming cells. 3. Effect in vivo. Immunology. 1970 Jan;18(1):61–72. [PMC free article] [PubMed] [Google Scholar]
  13. McNeill T. A. The antibody response of rabbits to inactivated vaccinia virus. J Hyg (Lond) 1965 Dec;63(4):525–535. doi: 10.1017/s0022172400045411. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. McNeill T. A. The neutralization of pox viruses. II. Relationships between vaccinia, rabbitpox, cowpox and ectromelia. J Hyg (Lond) 1968 Dec;66(4):549–555. doi: 10.1017/s0022172400028291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Metcalf D., Foster R. Bone marrow colony-stimulating activity of serum from mice with viral-induced leukemia. J Natl Cancer Inst. 1967 Dec;39(6):1235–1245. [PubMed] [Google Scholar]
  16. Metcalf D., Stanley E. R. Quantitative studies on the stimulation of mouse bone marrow colony growth in vitro by normal human urine. Aust J Exp Biol Med Sci. 1969 Aug;47(4):453–466. doi: 10.1038/icb.1969.50. [DOI] [PubMed] [Google Scholar]
  17. Metcalf D. Studies on colony formation in vitro by mouse bone marrow cells. I. Continuous cluster formation and relation of clusters to colonies. J Cell Physiol. 1969 Dec;74(3):323–332. doi: 10.1002/jcp.1040740313. [DOI] [PubMed] [Google Scholar]
  18. Moore M. A., McNeill T. A., Haskill J. S. Density distribution analysis of in vivo and in vitro colony forming cells in developing fetal liver. J Cell Physiol. 1970 Apr;75(2):181–192. doi: 10.1002/jcp.1040750207. [DOI] [PubMed] [Google Scholar]
  19. Pluznik D. H., Sachs L. The cloning of normal "mast" cells in tissue culture. J Cell Physiol. 1965 Dec;66(3):319–324. doi: 10.1002/jcp.1030660309. [DOI] [PubMed] [Google Scholar]
  20. SCHELL K. Studies on the innate resistance of mice to infection with mousepox. I. Resistance and antibody production. Aust J Exp Biol Med Sci. 1960 Aug;38:271–288. doi: 10.1038/icb.1960.29. [DOI] [PubMed] [Google Scholar]
  21. Wenner H. A., Cho C. T., Bolano C. R., Kamitsuka P. S. Studies on the pathogenesis of monkey pox. II. Dose-response and virus dispersion. Arch Gesamte Virusforsch. 1969;27(2):166–178. doi: 10.1007/BF01249641. [DOI] [PubMed] [Google Scholar]
  22. van Furth R., Cohn Z. A. The origin and kinetics of mononuclear phagocytes. J Exp Med. 1968 Sep 1;128(3):415–435. doi: 10.1084/jem.128.3.415. [DOI] [PMC free article] [PubMed] [Google Scholar]

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