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. 1971 Oct;4(4):397–401. doi: 10.1128/iai.4.4.397-401.1971

Age-Related Susceptibility to Haemophilus influenzae Type b Disease in Rabbits

Rachel Schneerson 1, John B Robbins 2
PMCID: PMC416320  PMID: 5317303

Abstract

Anti-type b antibodies were detected in newborns and in most 6- to 8-week-old rabbits, similar to those observed in humans. Culture of the pharynx and rectum of rabbits at varied ages failed to yield Haemophilus influenzae type b. Bacteria with cross-reacting antigens were observed in both the pharyngeal and rectal cultures from rabbits of varied ages. Rabbits without preexisting serum anti-type b antibodies were highly susceptible to septicemia and death after injection of small numbers of H. influenzae type b. Passively acquired antibody, whether observed in newborns or injected into animals without preexisting antibodies, conferred a high degree of protection against H. influenzae type b.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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