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. 1971 Oct;4(4):402–406. doi: 10.1128/iai.4.4.402-406.1971

Macrophage Cytophilic Antibody in Mice: Mechanism of Action of Bacterial Lipopolysaccharide on the Uptake of Immunoglobulins by Mouse Peritoneal Cells

Ian R Tizard a,1
PMCID: PMC416321  PMID: 5005300

Abstract

The action of injected bacterial lipopolysaccharide upon the uptake of cytophilic antibodies by macrophages was found to be unrelated either to changes in surface charge or to the rate of anaerobic glycolysis of these cells. It is apparently mediated by alterations in the levels of material in the serum which enhances the uptake of cytophilic antibody by macrophages. This enhancing material does not appear to be an immunoglobulin nor can it be generated by the action of endotoxin on either whole blood or serum.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BANGHAM A. D., HEARD D. H., FLEMANS R., SEAMAN G. V. An apparatus for microelectrophoresis of small particles. Nature. 1958 Sep 6;182(4636):642–644. doi: 10.1038/182642a0. [DOI] [PubMed] [Google Scholar]
  2. BERGMANN H., BUSCHMANN G., DOERING P., FRITZE E., WENDT F. Der Einfluss bakterieller Pyrogene (Lipopolysaccharide) auf die Phagocytoseaktivität der Granulocyten und auf die elektrische Oberflächenladung menschlichen Blutzellen in vivo. Klin Wochenschr. 1954 Jun 1;32(21-22):500–503. doi: 10.1007/BF01467091. [DOI] [PubMed] [Google Scholar]
  3. BIOZZI G., BENACERRAF B., HALPERN B. N. The effect of Salm. typhi and its endotoxin on the phagocytic activity of the reticuloendothelial system in mice. Br J Exp Pathol. 1955 Jun;36(3):226–235. [PMC free article] [PubMed] [Google Scholar]
  4. Dumonde D. C., Wolstencroft R. A., Panayi G. S., Matthew M., Morley J., Howson W. T. "Lymphokines": non-antibody mediators of cellular immunity generated by lymphocyte activation. Nature. 1969 Oct 4;224(5214):38–42. doi: 10.1038/224038a0. [DOI] [PubMed] [Google Scholar]
  5. Hill W. C., Rowley D. The origin of the antibody released into serum following injection of bacterial lipopolysaccharide. Aust J Exp Biol Med Sci. 1967 Dec;45(6):693–701. doi: 10.1038/icb.1967.69. [DOI] [PubMed] [Google Scholar]
  6. Jonas W. E., Gurner B. W., Nelson D. S., Coombs R. R. Passive sensitization of tissue cells. 1. Passive sensitization of macrophages by guinea-pig cytophilic antibody. Int Arch Allergy Appl Immunol. 1965;28(1):87–104. [PubMed] [Google Scholar]
  7. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  8. Michael J. G. The release of specific bactericidal antibodies by endotoxin. J Exp Med. 1966 Feb 1;123(2):205–212. doi: 10.1084/jem.123.2.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. ROWLEY D., TURNER K. J. INCREASE IN MACROGLOBULIN ANTIBODIES OF MOUSE AND PIG FOLLOWING INJECTION OF BACTERIAL LIPOPOLYSACCHARIDE. Immunology. 1964 Jul;7:394–402. [PMC free article] [PubMed] [Google Scholar]
  10. Tizard I. R. Macrophage cytophilic antibody in mice. The relationship between the adherence of antigen to macrophages mediated by macrophage-cytophilic antibodies and opsonic adherence antibodies. Int Arch Allergy Appl Immunol. 1970;39(2-3):201–209. [PubMed] [Google Scholar]
  11. Tizard I. R. Macrophage cytophilic antibody in mice: effect of bacterial lipopolysaccharide on the uptake of immunoglobulins by mouse peritoneal cells. Infect Immun. 1971 Mar;3(3):472–477. doi: 10.1128/iai.3.3.472-477.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. WESTPHAL O., LUDERITZ O. Uber die chemische und biologische Analyse hochgereinigter Bakterienpolysaccharide. Dtsch Med Wochenschr. 1953 May 22;78(21):17–19. [PubMed] [Google Scholar]
  13. WOODS M. W., LANDY M., WHITBY J. L., BURK D. Symposium on bacterial endotoxins. III. Metabolic effects of endotoxins on mammalian cells. Bacteriol Rev. 1961 Dec;25:447–456. doi: 10.1128/br.25.4.447-456.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]

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