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. 1971 Nov;4(5):563–566. doi: 10.1128/iai.4.5.563-566.1971

Comparison Between the Polymyxins and Gentamicin in Preventing Endotoxin-Induced Intravascular Coagulation and Leukopenia

James J Corrigan Jr 1, Bobbie M Bell 1
PMCID: PMC416353  PMID: 4343409

Abstract

Three antimicrobial agents were evaluated as to their ability to neutralize the toxic effects of endotoxin in rabbits. These consisted of two cyclic polypeptides, polymyxin B sulfate and colymycin M (sodium colistimethate), and an aminoglycoside, gentamicin sulfate. Polymyxin B regularly prevented endotoxin-induced leukopenia, thrombocytopenia, and disseminated intravascular coagulation. Colymycin M had similar activity but was not as effective as polymyxin B. Gentamicin demonstrated no neutralizing ability in this study.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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