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. 1971 Nov;4(5):589–592. doi: 10.1128/iai.4.5.589-592.1971

Passive Protection of Mice Against Intraperitoneally Injected Vibrio cholerae by γG and γM Antibody

Robert M Pike 1, Cleo H Chandler 1
PMCID: PMC416357  PMID: 5154896

Abstract

Fractions of rabbit anti-Vibrio cholerae serum containing γG antibodies were compared with fractions containing γM antibodies for their ability to protect mice against lethal infection resulting from the intraperitoneal injection of organisms suspended in mucin. About twice as much γG as γM (estimated by quantitative precipitation) was required to protect against approximately 1,000 50% lethal doses when the antibody was given intraperitoneally 4 hr before challenge. When protective serum fractions were given subcutaneously, however, the amount of γM required to protect was increased about 40-fold, whereas γG was about equally effective subcutaneously and intraperitoneally.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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