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. Author manuscript; available in PMC: 2015 Sep 26.
Published in final edited form as: Neuroscience. 2014 Jul 7;0:152–162. doi: 10.1016/j.neuroscience.2014.06.068

Figure 1.

Figure 1

Mapping of afferents from the auditory periphery to the cochlear nucleus complex. Precise topography (indicated by shades of blue in this and all subsequent figures) preserves centrally the frequency order established in the cochlea. The organ of Corti, SGNs, and their developing connections exhibit complex complementary and overlapping Eph/ephrin expression patterns. Guidance mechanisms involving both subfamilies are responsible for accurate circuit assembly (inset key). Inner radial bundle formation and proper fasciculation require ephrin-B2/EphA4 signaling between growing SGN peripheral processes and the surrounding otic mesenchyme. Ephrin-A5-expressing outer hair cells (OHCs) repel EphA4-positive type I SGNs that preferentially map to the inner hair cell (IHCs) rank. A subpopulation of type I SGNs are ephrin-A5-positive (purple stripes). LF = low frequency, HF = high frequency.