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. 2014 Jul 25;155(10):4104–4112. doi: 10.1210/en.2014-1154

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Copyright © 2014 by the Endocrine Society

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Figure 1. — Effects of PTU or PBDE treatment on maternal hormone concentrations. A, Serum total T₄ levels in dams at the time the animals were killed on P21, after PTU (solid bars) or PBDE (open bars) treatment. A one-way ANOVA was performed separately for each of the two experiments. For PTU, F_3,28 = 27.12; P < .0001; for PBDE, F_4,31 = 14.02; P < .001. B, Serum free T₄ levels in dams after PTU (solid bars) or PBDE (open bars) treatment. For PTU, F_{3, 27} = 20.90; P < .0001; for PBDE, F_{4, 31} = 11.71; P < .0001. C, Serum total T₃ in dams treated with PTU (solid bars) or PBDE (open bars) treatment. One-way ANOVA revealed no significant differences among treatment groups. D, Serum TSH in dams treated with PTU (solid bars) or PBDE (open bars). For PTU, a one-way ANOVA demonstrated that TSH levels were significantly increased (F_{3, 51} = 14.83; P < .0001). This was not the case for PBDE, in which F_4,29 = 1.37; P = .27. Bars represent mean ± SEM (n = 5–10 per group). *, P < .05; ***, P < .0001.