Figure 7.

Ablation of mouse β-cell TASK-1 results in increased glucose-stimulated Ca²⁺ influx. A, Mouse islet Ca²⁺ responses from control (black trace, islets from tamoxifen-treated MIP-Cre/ERT mice, n = 72) and TASK-1 β-cell ablation backgrounds (gray trace, islets from tamoxifen-treated KCNK3 floxed MIP-Cre/ERT mice, n = 76) switching from 2mM glucose to 14mM glucose (black bar above). B, Area under the Ca²⁺ influx curve of the control (black bars) and TASK-1 β-cell ablation (gray bars) mouse islets for the first 8 minutes in 14mM glucose, from 8 to 13 minutes in glucose, and for 10 minutes immediately after reduction of glucose from 14mM to 2mM (±SEM; *, P < .05; **, P < .01).