Table 1.

Differences between GAP-43 (+/+) and (−/−) mice in area of each cerebellar folia and depth of each fissure

Zone	Folia	Area as % of (+/+)	Fissure	Depth as % of (+/+).
AZ	I–II	57±6.1*	Fprc	64.1±3.7*
	III	79±14.7	Fpc	70±4.7
	IV–V	93±6.4
CZ	VI–VII	43±9.8*	Fpr	77±3.0*
PZ	VIII	86±5.6	Fppd	74±10.9*
NZ	IX	75±8.7*	Fsec	87±4.0*
	X	66±6.1**	Fpl	68±7.6*

Brains from six littermate pairs of GAP-43 (+/+) and (−/−) P21 mice were fixed in 4% PFA and 14-µm paraffin parasagittal sections at the vermis Nissl-stained. The area occupied by each folia (delineated from the base of the adjacent fissure) and the depth of each fissure was calculated from digital images of sections taken from the vermis using IP lab. Results are expressed as ±SEM. Folia in the anterior, central, and nodular zones were all reduced in size. Likewise, the secondary fissures within each folia were also significantly reduced in depth.

^*p<0.05,

^**p<0.001, two sided Mann–Whitney test, n=6