Table 2.
Number (%) of neonates who ever had a score >0.
| NAS sign | Methadone (n = 72) | Buprenorphine (n = 57) | χ2 P-value |
|---|---|---|---|
| Total score | 72 (100) | 57 (100) | 1.00 |
| Disturbed tremors | 72 (100) | 55 (96) | 0.11 |
| Increased muscle tone | 71 (99) | 57 (100) | 0.37 |
| Sleep | 65 (90) | 55 (96) | 0.17 |
| Tachypnea | 62 (86) | 51 (89) | 0.57 |
| Fever | 61 (85) | 53 (93) | 0.15 |
| Undisturbed tremors | 58 (81) | 36 (63) | 0.03 |
| Hyperactive Moro reflex | 55 (76) | 33 (58) | 0.03 |
| Sneezing | 55 (76) | 53 (93) | 0.01 |
| Crying | 40 (56) | 32 (56) | 0.94 |
| Excessive irritability | 39 (54) | 38 (67) | 0.15 |
| Poor feeding | 39 (54) | 28 (49) | 0.57 |
| Vomiting | 38 (53) | 33 (58) | 0.56 |
| Excoriation | 34 (47) | 32 (56) | 0.31 |
| Loose stools | 33 (46) | 40 (70) | 0.01 |
| Nasal stuffiness | 20 (28) | 29 (51) | 0.01 |
| Frequent yawning | 15 (21) | 17 (30) | 0.24 |
| Sweating | 15 (21) | 12 (21) | 0.98 |
| Failure to thrive | 12 (17) | 7 (12) | 0.49 |
| Generalized seizure | 0 | 2 (4) | 0.11 |
Entries shown in bold type indicate significant differences between medication conditions. NAS = neonatal abstinence syndrome.