FIGURE 4.

mGluR5 immunohistochemical expression in human hippocampal formation: dentate gyrus. Representative mGluR5 staining patterns in HS (A: hippocampal head; D: hippocampal body), non-HS (B: hippocampal head; E: hippocampal body) and control group (C: hippocampal head; F: hippocampal body). HS and non-HS hippocampal head and body showed strong immunostaining when compared to controls. HS and non-HS dentate gyrus OML presented an enhancement of mGluR5 immunoreactivity in relation to IML (G). Such feature was not evident in control dentate gyrus (G, right). Strong mGluR5 staining was also found in postsynaptic terminals as primary dendrites in the hilus (H left, arrows) and in astrocytic-like cells in the dentate gyrus (H right, arrow heads). GL, granular layer; OML, outer molecular layer; IML, inner molecular layer. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]