Table 1. Reported Docking Motifs and Corresponding Binding Affinities for Specific MAP Kinase23.
KD (μM) |
||||||
---|---|---|---|---|---|---|
kinase | docking motif | docking domain sequence | JNK | p38 | ERK | orientation |
JNK | NFAT4 | ERPSRDHLYLPLEP | 7.1 | >100 | >100 | forward |
p38 | MK2 | IKIKKIEDASNPLLLKRRKK | >100 | 0.05 | 19.5 | reverse |
ERK | RSK1 | PQLKPIESSILAQRRVRKL | >100 | 0.3 | 23 | reverse |