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. 2014 Sep 10;4(11):1145–1152. doi: 10.7150/thno.10006

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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T1-weighted images (T1WI) of mice bearing breast cancer xenografts in all four treatment groups, demonstrating homogeneous hypointense tumor masses (arrows) on the animals' unilateral back. The tumor masses become hyperintense after intravenous administration of gadolinium (enhanced T1WI). The follow-up imaging of tumor growth at different time points shows that tumor size in the chemo plus radiofrequency heat (RFH) group (s-x) clearly decreases at week 2 after treatment (arrow on x), in comparison to those in the control (a-f), RFH-only (g-l), and chemo-only (m-r) groups.