Table 2.
Symptoms and Biomarkers in IC/BPS patients and Healthy Controls. Inflammatory variables are adjusted for BMI. GUPI=Genitourinary Pain Index, IC= Interstitial Cystitis, BPS=Bladder Pain Syndrome, FSFI=Female Sexual Functioning Inventory. IL-6=Interleukin-6. IL-1β=Interleukin-1 beta. LPS= Lipopolysaccharide. SAC= Staphylococcus aureus Cowan.
| Variable Mean (95% CI) | IC/BPS n=58 |
Healthy Controls n=28 |
p |
|---|---|---|---|
| GUPI score total |
24.7 (22.7,26.8) | 1.4(.5,2.3) | <.001 |
| GUPI score pain | 12.0(10.8,13.1) | .3(−.1,.6) | <.001 |
| GUPI score urinary subscale | 5.6(4.8,6.4) | .7(.3,1.1) | <.001 |
| IC Symptom Index | 10.5(9.3,11.6) | 2.5(1.6,3.5) | <.001 |
| FSFI total | 16.5(13.78,19.1) | 25.3(21.2,29.5) | <.001 |
| FSFI Pain | 6.00(4.5,7.4) | 11.9(9.7,14.1) | <.001 |
| Morning Cortisola nmol/L |
2.55 (2.40, 2.71) | 2.75 (2.54, 2.96) | .14c |
| Afternoon Cortisola nmol/L |
1.48 (1.28, 1.67) | 1.17 (.90, 1.44) | .07c |
| Nocturnal Cortisola nmol/L |
1.13 (.91, 1.36) | .66 (.35, .97) | .019c |
| Cortisol Slopea nmol/L, hourly decrease |
−.10(−.12, −.08) | −.14(−.17, −.12) | .010 |
| IL-6 plasmab pg/mL |
.45(.39,.52) | .34(.25,.43) | .040 |
| IL-β + LPSb pg/mL |
3.34(3.16,3.50) | 3.53(3.27,3.77) | .24 |
| IL-β + SACb pg/mL |
1.22(.93,1.52) | .67(.24,1.10) | .039 |
| IL-6 + LPSb pg/mL |
4.20(4.09,4.31) | 4.13(3.96,4.29) | .48 |
| IL-6 + SACb pg/mL |
1.71(1.35,2.07) | 1.15(.63,1.67) | .09 |
a
natural log transformed
b
log 10 transformed
c
post-hoc comparison by Sidak adjustment