Table 3. Patient Characteristics Including Details about Anesthetic Exposures and Surgeries as well as Primary Outcomes for each Patient.
|
MAC ×
min |
IV agents,
total |
Primary
outcomes |
||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Diagnosis | Type of surgery | Age | Sex | Age at 1st exposure | Kg at 1st exposure | Anesthetics before age 2 | Exposed after age 2 | Anesthetic duration | N20 | Halothane | Isoflurane | Sevoflurane | Sum | Propofol (mg) | Fentanyl (mcg) | IQ | Color R | Color F | Spatial R | Spatial F |
| Hip dysplasias, chronic skin ulcer | Bilateral open reduction | 6.09 | F | 0.48 | 7 | 3 | Yes | 572 | 191.00 | 481.00 | 218.00 | 186.50 | 1,077 | 0 | 20 | 98.00 | 0.49 | 1.97 | 0.70 | 0.75 |
| Ureterocele | Cystoscopy/circumcision | 7.29 | M | 0.27 | 6 | 2 | No | 257 | 57.50 | 0.00 | 66.30 | 168.00 | 292 | 0 | 0 | 125.00 | 0.01 | 1.52 | 0.35 | 0.54 |
| Cleft lip | Cleft lip repair | 9.88 | F | 0.25 | 6 | 1 | No | 120 | 35.00 | 0.00 | 63.60 | 37.50 | 136 | 0 | 15 | 107.00 | 0.12 | 0.51 | 0.62 | 1.87 |
| Ureterocele | Ureteral endopuncture | 6.81 | M | 0.19 | 6 | 2 | No | 199 | 99.50 | 0.00 | 150.00 | 105.00 | 355 | 0 | 10 | 101.00 | 0.03 | 0.33 | 0.12 | 0.00 |
| Hypospadias | Hypospadias repair | 10.06 | M | 0.58 | 10 | 1 | No | 133 | 81.00 | 157.00 | 0.00 | 0.00 | 238 | 20 | 10 | 66.00 | 0.00 | 0.00 | 0.46 | 0.02 |
| Right eyelid hemangioma | Right eyelid hemangioma injection | 10.00 | F | 0.93 | 8 | 1 | No | 15 | 10.00 | 14.00 | 0.00 | 16.00 | 40 | 0 | 0 | 108.00 | 0.32 | 0.74 | 0.73 | 1.69 |
| Pulmonary sequestration | Thoracoscopy, thoracotomy, resection of pulmonary sequestration | 6.90 | M | 0.73 | 9 | 1 | No | 195 | 32.40 | 0.00 | 0.00 | 297.00 | 329 | 0 | 0 | 117.00 | 0.38 | 0.00 | 0.14 | 0.31 |
| Polydactyly | Excision of extra member | 10.22 | M | 0.38 | 7 | 1 | No | 194 | 100.00 | 0.00 | 0.00 | 159.00 | 259 | 0 | 35 | 109.00 | 0.38 | 0.43 | 0.27 | 0.66 |
| Hypospadias | Hypospadias repair | 10.49 | M | 0.55 | 7 | 2 | No | 235 | 110.00 | 130.00 | 0.00 | 115.00 | 355 | 0 | 8 | 136.00 | 0.41 | 0.60 | 0.35 | 1.74 |
| Tethered cord | Tethered cord release | 6.90 | F | 0.61 | 9 | 5 | Yes | 613 | 115.00 | 0.00 | 58.30 | 329.00 | 502 | 50 | 50 | 120.00 | 0.27 | 0.35 | 0.23 | 1.59 |
| Sebaceous cyst | Excision | 11.53 | F | 0.73 | 8 | 1 | No | 97 | 40.00 | 56.00 | 76.00 | 0.00 | 172 | 0 | 0 | 100.00 | 0.44 | 0.81 | 0.51 | 0.70 |
| Sternal notch mass | Excision | 9.29 | M | 0.53 | 8 | 1 | No | 45 | 18.00 | 0.00 | 71.00 | 48.00 | 137 | 0 | 0 | 110.00 | 0.45 | 0.00 | 0.57 | 1.13 |
| Anal fistula | Anal fistulectomy | 9.88 | M | 0.24 | 5 | 2 | No | 77 | 28.60 | 0.00 | 40.80 | 100.00 | 169 | 0 | 5 | 116.00 | 0.27 | 1.19 | 0.19 | 1.59 |
| Testicular torsion | Left orchidopexy | 10.05 | M | 0.18 | 6 | 1 | No | 117 | 12.00 | 0.00 | 0.00 | 47.00 | 59 | 0 | 0 | 107.00 | 0.49 | 0.44 | 0.12 | 0.00 |
| Umbilical hernia and perauricular lesion | Repair and excision | 10.46 | M | 0.27 | 6 | 1 | No | 87 | 56.00 | 0.00 | 56.00 | 38.00 | 150 | 0 | 5 | 124.00 | 0.49 | 1.58 | 0.38 | 0.86 |
| Left complex bifid thumb (duplication) | Amputation | 9.66 | F | 0.54 | 7 | 1 | No | 113 | 38.00 | 0.00 | 39.00 | 123.00 | 200 | 0 | 0 | 116.00 | 0.06 | 0.00 | 0.50 | 0.12 |
| Vesicourethral reflux | Bilateral urethral reimplantation | 11.81 | F | 0.93 | 10 | 1 | No | 166 | 26.00 | 0.00 | 0.00 | 207.00 | 233 | 0 | 5 | 96.00 | 0.84 | 0.00 | 0.31 | 1.33 |
| Hypospadias | Hypospadia repair | 10.75 | M | 0.90 | 12 | 1 | No | 128 | 58.00 | 0.00 | 0.00 | 90.00 | 148 | 0 | 0 | 113.00 | 0.23 | 0.56 | 0.34 | 0.85 |
| Hypospadias | Hypospadia repair | 9.78 | M | 0.47 | 6 | 1 | No | 110 | 50.50 | 0.00 | 0.00 | 128.00 | 179 | 0 | 5 | 118.00 | 0.75 | 1.89 | 0.42 | 0.88 |
| Bilateral inguinal hernias | Bilateral inguinal hernia repair | 6.41 | M | 0.33 | 8 | 1 | No | 156 | 90.00 | 0.00 | 0.00 | 115.00 | 205 | 0 | 10 | 86.00 | 0.16 | 0.56 | 0.00 | 0.00 |
| Vascular malformation left hand | Left hand sclerosis | 7.75 | M | 0.91 | 10 | 2 | Yes | 385 | 13.00 | 0.00 | 0.00 | 462.60 | 476 | 40 | 25 | 146.00 | 0.23 | 0.92 | 0.69 | 1.19 |
| Hypospadia | Hypospadias repair | 9.67 | M | 0.61 | 9 | 1 | No | 125 | 57.00 | 0.00 | 0.00 | 122.00 | 179 | 0 | 0 | 100.00 | 0.21 | 0.33 | 0.27 | 0.64 |
| Vesicourethral reflux | Vesicoureteral reimplantation, cystogram | 10.31 | F | 0.86 | 10 | 1 | No | 179 | 101.00 | 0.00 | 0.00 | 97.00 | 198 | 0 | 0 | 96.00 | 0.33 | 0.49 | 0.21 | 0.00 |
| Giant hairy nevus | Resect and skin graft from buttocks | 11.25 | F | 0.48 | 7 | 1 | No | 316 | 151.00 | 0.00 | 206.00 | 24.00 | 381 | 0 | 70 | 115.00 | 0.43 | 0.94 | 0.48 | 1.56 |
| Clubfoot | Achilles tenotomy; tendon lengthening; leg cast | 10.77 | M | 0.31 | 7 | 4 | No | 245 | 123.00 | 79.00 | 24.00 | 84.00 | 310 | 0 | 0 | 128.00 | 0.60 | 2.23 | 0.53 | 1.32 |
| Hypospadias | Complex hypospadias repair | 9.39 | M | 0.60 | 10 | 1 | No | 138 | 63.00 | 114.00 | 0.00 | 24.00 | 201 | 0 | 15 | 137.00 | 0.33 | 0.92 | 0.27 | 0.15 |
| Bilateral inguinal hernias | Bilateral inguinal hernia repair | 11.23 | M | 0.67 | 10 | 1 | No | 123 | 80.00 | 0.00 | 49.00 | 18.00 | 147 | 0 | 25 | 108.00 | 0.49 | 0.97 | 0.52 | 1.02 |
| Hypospadias | Complex hypospadias repair | 8.77 | M | 0.48 | 8 | 1 | No | 138 | 68.00 | 0.00 | 0.00 | 139.00 | 207 | 0 | 5 | 125.00 | 0.20 | 0.73 | 0.20 | 0.91 |
Abbreviations: F, familiarity index; kg, weight in kilograms; MAC, minimum alveolar concentration; N20, nitrous oxide; R, recollection index.
Age refers to the age at testing, calculated as years+(days/365) and rounded to 1 decimal point. Age at 1st exposure is likewise expressed as (a fraction of) years and rounded to 2 decimal points.