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. 1995 Jun 6;92(12):5351–5355. doi: 10.1073/pnas.92.12.5351

Purification and identification of pituitary cytotropic factor.

J C Porter 1, C F Ijames 1, T C Wang 1, S P Markey 1
PMCID: PMC41692  PMID: 7777510

Abstract

It has been shown that the pituitary contains a cytotropic factor (CTF) that stimulates the secretion of catecholamines by dopaminergic neurons of the hypothalamus. In the present study, CTF was purified from rat pituitaries and found by means of mass spectrometric analysis to be adenosine. This finding was corroborated by the observations that CTF behaves identically to adenosine when subjected to liquid chromatography, is inactivated and converted to inosine by adenosine deaminase, and is qualitatively and quantitatively indistinguishable from adenosine in its biological activity. It is concluded that pituitary adenosine is a trophic factor for hypothalamic dopaminergic neurons.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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