Figure 4. Decreased Ron activity in the prostates of HGFL-/- TRAMP+ animals.

A). Ron expression levels are similar in HGFL+/+ TRAMP+ and HGFL-/- TRAMP+ mice prostate tumors as judged by Western blot and qRT-PCR analyses. qRT-PCR analysis shows representative data from 2 independent experiments (n=4 mice per group). B). Ron kinase activity is decreased in prostate tumors from HGFL -/- TRAMP+ compared to HGFL+/+ TRAMP+ mice as depicted by kinase assays examining myelin basic protein (MBP) as a substrate. Graph shows combined data from 5 independent experiments (n=4 mice per group) ± SE normalized to Ron expression levels in A. *P<0.05.