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. 1995 Jun 6;92(12):5426–5430. doi: 10.1073/pnas.92.12.5426

Library of libraries: approach to synthetic combinatorial library design and screening of "pharmacophore" motifs.

N F Sepetov 1, V Krchnák 1, M Stanková 1, S Wade 1, K S Lam 1, M Lebl 1
PMCID: PMC41707  PMID: 7777524

Abstract

Construction of synthetic combinatorial libraries is described that allows for the generation of a library of motifs rather than a library of compounds. Peptide libraries based on this strategy were synthesized and screened with model targets streptavidin and anti-beta-endorphin antibody. The screens resulted in observation of expected motifs providing evidence of the effectiveness of the suggested approach.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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