Figure 4. XmAb5871 inhibits BCR and TLR9-induced IL-6, IL-10 and TNF production by B cells. B cells cultured in 96-well plates were activated by 2.5 μg/ml anti-Ig or 1 μg/ml CpG ODN in the presence of XmAb5871 or the control antibody XENP6187. IL-6, IL-10 and TNF secreted from the culture supernatants were measured after 48 h using the Flow Cytomix bead array. Data represent the mean ± SD of four independent experiments. XmAb5871 significantly inhibits IL-6 production induced by anti-Ig and CpG, as compared with XENP6187 treated cells. *: P < 0.05.