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. 2014 Jul 14;5(15):6338–6352. doi: 10.18632/oncotarget.2215

Figure 4. Impact of PRC1 and PRC2 depletion on DNA methylation patterns.

Figure 4

(A) Tag density plots of methylation from −5 to +5 kb across gene promoters at high CpG density loci (HCP), intermediate CpG density loci (ICP), and low CpG density loci (LCP) as defined in [43]. (B) Tag density plots of methylation across CGI located in promoters, gene bodies, and intergenic regions. (C) Pie charts for genes with >2-fold decreased and increased 5mC in promoters, gene bodies, CGI, and CGI shores. (D-E) Bar graphs illustrate the proportion of CGI in promoters, gene bodies, and downstream of genes that become hypomethylated (D) or hypermethylated (E) in each siRNA depletion.