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A: Representation of ZnT8 with predicted positions of amino acid residues for transmembrane, cytosolic, and luminal/extracellular segments (TMHMM v2.0). Four immunogenic epitopes are marked (not drawn to scale). Synopsis of T-cell epitopes (B) and B-cell epitopes (C) on ZnT8. Ext, extracellular; LADA, latent autoimmune diabetes of adult; Sp, signal peptide; TM, transmembrane.
