Table 2.

Retinal layer thickness for each of the healed cotton wool spot and their corresponding control areas.

Retinal Layer	Mean Thickness Healed CWS ±SD (microns)	Mean Thickness control CWS ±SD (microns)	Median Thickness of Healed CWS (microns)	Median Thickness Control CWS (microns)	mean diff±SD (microns)	Range (microns) Healed CWS	Range (microns) Control CWS	P value*
NFL	59.21 ± 30.15	66.58 ± 34.2	53	57	7.37±13.72	21 – 147	33 – 170	0.037
GCL	7.52 ± 6.22	13.31 ± 6.4	8	12	5.79±7.62	0 – 18	6 – 30	0.012
IPL	26.15 ± 9.09	31.36 ± 9.12	25	29	5.21±10.36	9 – 49	17 – 48	0.042
INL	18.52 ± 6.85	24.63 ± 7.22	18	24	6.11+11.12	6 – 36	16 – 44	0.037
OPL	17.63 ± 6.00	21.94 ± 4.49	17	23	4.32±6.35	6 – 31	15 – 30	0.017
ONL	80.15 ± 15.78	69.42 ± 9.05	81	70	−10.74±11.65	48 – 108	46 – 82	0.005

CWS = cotton wool spot, diff = difference, SD = standard deviation, Layer: NFL = nerve fiber layer, GCL = ganglion cell layer, IPL = Inner Plexiform Layer, INL = inner nuclear layer, OPL = outer plexiform layer, ONL = Outer nuclear layer. SD = standard deviation.

Note Outer Nuclear layer is expanded in HIV eyes; it is expanded into thinned inner retina.

^*p value is corrected to avoid false discovery associated with multiple comparisons, see methods.