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. 2014 Sep 24;9(9):e107979. doi: 10.1371/journal.pone.0107979

Figure 1. Effects of nicotine and non-nicotine components of cigarette smoke on EAE severity.

Figure 1

EAE was induced by injection of MOG35–55 in CFA and pertussis toxin. (A) CSC was infused at 10 or 20 mg/ml into EAE mice starting at day 0 of EAE for 28 days, with DMSO as vehicle. (B) 20 mg/ml CSC was infused into the mice from 14 days prior to EAE induction through day 28, with 50% DMSO as vehicle. (C) Nicotine (200 mg/ml) was infused into EAE mice starting at Day 0 of EAE for 28 days, with saline as vehicle. Peak score (D) and cumulative score (E) were compared between CSC (n = 3)/nicotine (n = 6) and control mice (n = 8). (*** p<0.001; **p<0.01; *p<0.05).