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(A) 14-day pumps filled with 200 mg/ml nicotine were placed in the backs of EAE mice at day 14 (***<0.001). Peak score (B) as well as cumulative score (C) from day 14 to day 28 were recorded and compared between the vehicle (n = 8) and nicotine-treated (n = 3) groups. (D) Weekly weights were plotted as a percentage of day 0 weights. (***p<0.001; *p<0.05)
