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. 1995 May 23;92(11):4721–4724. doi: 10.1073/pnas.92.11.4721

Mechanisms for the pleiotropic effects of the agouti gene.

J Manne 1, A C Argeson 1, L D Siracusa 1
PMCID: PMC41778  PMID: 7761389

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berridge M. J. Inositol trisphosphate and calcium signalling. Nature. 1993 Jan 28;361(6410):315–325. doi: 10.1038/361315a0. [DOI] [PubMed] [Google Scholar]
  2. Branton W. D., Kolton L., Jan Y. N., Jan L. Y. Neurotoxins from Plectreurys spider venom are potent presynaptic blockers in Drosophila. J Neurosci. 1987 Dec;7(12):4195–4200. doi: 10.1523/JNEUROSCI.07-12-04195.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bultman S. J., Klebig M. L., Michaud E. J., Sweet H. O., Davisson M. T., Woychik R. P. Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts. Genes Dev. 1994 Feb 15;8(4):481–490. doi: 10.1101/gad.8.4.481. [DOI] [PubMed] [Google Scholar]
  4. Bultman S. J., Michaud E. J., Woychik R. P. Molecular characterization of the mouse agouti locus. Cell. 1992 Dec 24;71(7):1195–1204. doi: 10.1016/s0092-8674(05)80067-4. [DOI] [PubMed] [Google Scholar]
  5. Clapham D. E. Calcium signaling. Cell. 1995 Jan 27;80(2):259–268. doi: 10.1016/0092-8674(95)90408-5. [DOI] [PubMed] [Google Scholar]
  6. Clapham D. E., Neer E. J. New roles for G-protein beta gamma-dimers in transmembrane signalling. Nature. 1993 Sep 30;365(6445):403–406. doi: 10.1038/365403a0. [DOI] [PubMed] [Google Scholar]
  7. Cole K., Kohn E. Calcium-mediated signal transduction: biology, biochemistry, and therapy. Cancer Metastasis Rev. 1994 Mar;13(1):31–44. doi: 10.1007/BF00690417. [DOI] [PubMed] [Google Scholar]
  8. Colledge C. J., Hunsperger J. P., Imperial J. S., Hillyard D. R. Precursor structure of omega-conotoxin GVIA determined from a cDNA clone. Toxicon. 1992 Sep;30(9):1111–1116. doi: 10.1016/0041-0101(92)90056-b. [DOI] [PubMed] [Google Scholar]
  9. Draznin B. Cytosolic calcium and insulin resistance. Am J Kidney Dis. 1993 Jun;21(6 Suppl 3):32–38. doi: 10.1016/0272-6386(93)70122-f. [DOI] [PubMed] [Google Scholar]
  10. Duhl D. M., Stevens M. E., Vrieling H., Saxon P. J., Miller M. W., Epstein C. J., Barsh G. S. Pleiotropic effects of the mouse lethal yellow (Ay) mutation explained by deletion of a maternally expressed gene and the simultaneous production of agouti fusion RNAs. Development. 1994 Jun;120(6):1695–1708. doi: 10.1242/dev.120.6.1695. [DOI] [PubMed] [Google Scholar]
  11. Duhl D. M., Vrieling H., Miller K. A., Wolff G. L., Barsh G. S. Neomorphic agouti mutations in obese yellow mice. Nat Genet. 1994 Sep;8(1):59–65. doi: 10.1038/ng0994-59. [DOI] [PubMed] [Google Scholar]
  12. Feigenbaum P., Garcia M. L., Kaczorowski G. J. Evidence for distinct sites coupled to high affinity omega-conotoxin receptors in rat brain synaptic plasma membrane vesicles. Biochem Biophys Res Commun. 1988 Jul 15;154(1):298–305. doi: 10.1016/0006-291x(88)90684-5. [DOI] [PubMed] [Google Scholar]
  13. Jackson I. J. More to colour than meets the eye. Curr Biol. 1993 Aug 1;3(8):518–521. doi: 10.1016/0960-9822(93)90045-p. [DOI] [PubMed] [Google Scholar]
  14. Kelly K. L., Deeney J. T., Corkey B. E. Cytosolic free calcium in adipocytes. Distinct mechanisms of regulation and effects on insulin action. J Biol Chem. 1989 Aug 5;264(22):12754–12757. [PubMed] [Google Scholar]
  15. Klebig M. L., Wilkinson J. E., Geisler J. G., Woychik R. P. Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur. Proc Natl Acad Sci U S A. 1995 May 23;92(11):4728–4732. doi: 10.1073/pnas.92.11.4728. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Kwon H. Y., Bultman S. J., Löffler C., Chen W. J., Furdon P. J., Powell J. G., Usala A. L., Wilkison W., Hansmann I., Woychik R. P. Molecular structure and chromosomal mapping of the human homolog of the agouti gene. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9760–9764. doi: 10.1073/pnas.91.21.9760. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Leung H. T., Branton W. D., Phillips H. S., Jan L., Byerly L. Spider toxins selectively block calcium currents in Drosophila. Neuron. 1989 Dec;3(6):767–772. doi: 10.1016/0896-6273(89)90245-6. [DOI] [PubMed] [Google Scholar]
  18. Levy J., Gavin J. R., 3rd, Sowers J. R. Diabetes mellitus: a disease of abnormal cellular calcium metabolism? Am J Med. 1994 Mar;96(3):260–273. doi: 10.1016/0002-9343(94)90152-x. [DOI] [PubMed] [Google Scholar]
  19. Lu D., Willard D., Patel I. R., Kadwell S., Overton L., Kost T., Luther M., Chen W., Woychik R. P., Wilkison W. O. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature. 1994 Oct 27;371(6500):799–802. doi: 10.1038/371799a0. [DOI] [PubMed] [Google Scholar]
  20. Lundy P. M., Frew R. Evidence of mammalian Ca2+ channel inhibitors in venom of the spider Plectreurys tristis. Toxicon. 1993 Oct;31(10):1249–1256. doi: 10.1016/0041-0101(93)90398-3. [DOI] [PubMed] [Google Scholar]
  21. Means A. R. Calcium, calmodulin and cell cycle regulation. FEBS Lett. 1994 Jun 20;347(1):1–4. doi: 10.1016/0014-5793(94)00492-7. [DOI] [PubMed] [Google Scholar]
  22. Michaud E. J., Bultman S. J., Klebig M. L., van Vugt M. J., Stubbs L. J., Russell L. B., Woychik R. P. A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2562–2566. doi: 10.1073/pnas.91.7.2562. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Michaud E. J., Bultman S. J., Stubbs L. J., Woychik R. P. The embryonic lethality of homozygous lethal yellow mice (Ay/Ay) is associated with the disruption of a novel RNA-binding protein. Genes Dev. 1993 Jul;7(7A):1203–1213. doi: 10.1101/gad.7.7a.1203. [DOI] [PubMed] [Google Scholar]
  24. Michaud E. J., van Vugt M. J., Bultman S. J., Sweet H. O., Davisson M. T., Woychik R. P. Differential expression of a new dominant agouti allele (Aiapy) is correlated with methylation state and is influenced by parental lineage. Genes Dev. 1994 Jun 15;8(12):1463–1472. doi: 10.1101/gad.8.12.1463. [DOI] [PubMed] [Google Scholar]
  25. Miller M. W., Duhl D. M., Vrieling H., Cordes S. P., Ollmann M. M., Winkes B. M., Barsh G. S. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev. 1993 Mar;7(3):454–467. doi: 10.1101/gad.7.3.454. [DOI] [PubMed] [Google Scholar]
  26. Nicotera P., Zhivotovsky B., Orrenius S. Nuclear calcium transport and the role of calcium in apoptosis. Cell Calcium. 1994 Oct;16(4):279–288. doi: 10.1016/0143-4160(94)90091-4. [DOI] [PubMed] [Google Scholar]
  27. Olivera B. M., Miljanich G. P., Ramachandran J., Adams M. E. Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins. Annu Rev Biochem. 1994;63:823–867. doi: 10.1146/annurev.bi.63.070194.004135. [DOI] [PubMed] [Google Scholar]
  28. Olivera B. M., Rivier J., Clark C., Ramilo C. A., Corpuz G. P., Abogadie F. C., Mena E. E., Woodward S. R., Hillyard D. R., Cruz L. J. Diversity of Conus neuropeptides. Science. 1990 Jul 20;249(4966):257–263. doi: 10.1126/science.2165278. [DOI] [PubMed] [Google Scholar]
  29. Olivera B. M., Rivier J., Scott J. K., Hillyard D. R., Cruz L. J. Conotoxins. J Biol Chem. 1991 Nov 25;266(33):22067–22070. [PubMed] [Google Scholar]
  30. Pozzan T., Rizzuto R., Volpe P., Meldolesi J. Molecular and cellular physiology of intracellular calcium stores. Physiol Rev. 1994 Jul;74(3):595–636. doi: 10.1152/physrev.1994.74.3.595. [DOI] [PubMed] [Google Scholar]
  31. Quistad G. B., Skinner W. S. Isolation and sequencing of insecticidal peptides from the primitive hunting spider, Plectreurys tristis (Simon). J Biol Chem. 1994 Apr 15;269(15):11098–11101. [PubMed] [Google Scholar]
  32. Resnick L. M. Ionic basis of hypertension, insulin resistance, vascular disease, and related disorders. The mechanism of "syndrome X". Am J Hypertens. 1993 Apr;6(4):123S–134S. doi: 10.1093/ajh/6.4s.123s. [DOI] [PubMed] [Google Scholar]
  33. Roth R. A., Liu F., Chin J. E. Biochemical mechanisms of insulin resistance. Horm Res. 1994;41 (Suppl 2):51–55. doi: 10.1159/000183961. [DOI] [PubMed] [Google Scholar]
  34. Siracusa L. D. The agouti gene: turned on to yellow. Trends Genet. 1994 Dec;10(12):423–428. doi: 10.1016/0168-9525(94)90112-0. [DOI] [PubMed] [Google Scholar]
  35. Stewart B. W. Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators. J Natl Cancer Inst. 1994 Sep 7;86(17):1286–1296. doi: 10.1093/jnci/86.17.1286. [DOI] [PubMed] [Google Scholar]
  36. Tsien R. W., Tsien R. Y. Calcium channels, stores, and oscillations. Annu Rev Cell Biol. 1990;6:715–760. doi: 10.1146/annurev.cb.06.110190.003435. [DOI] [PubMed] [Google Scholar]
  37. Vrieling H., Duhl D. M., Millar S. E., Miller K. A., Barsh G. S. Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5667–5671. doi: 10.1073/pnas.91.12.5667. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Wilson B. D., Ollmann M. M., Kang L., Stoffel M., Bell G. I., Barsh G. S. Structure and function of ASP, the human homolog of the mouse agouti gene. Hum Mol Genet. 1995 Feb;4(2):223–230. doi: 10.1093/hmg/4.2.223. [DOI] [PubMed] [Google Scholar]
  39. Woodward S. R., Cruz L. J., Olivera B. M., Hillyard D. R. Constant and hypervariable regions in conotoxin propeptides. EMBO J. 1990 Apr;9(4):1015–1020. doi: 10.1002/j.1460-2075.1990.tb08204.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Yen T. T., Gill A. M., Frigeri L. G., Barsh G. S., Wolff G. L. Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene. FASEB J. 1994 May;8(8):479–488. doi: 10.1096/fasebj.8.8.8181666. [DOI] [PubMed] [Google Scholar]
  41. Zemel M. B., Kim J. H., Woychik R. P., Michaud E. J., Kadwell S. H., Patel I. R., Wilkison W. O. Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice. Proc Natl Acad Sci U S A. 1995 May 23;92(11):4733–4737. doi: 10.1073/pnas.92.11.4733. [DOI] [PMC free article] [PubMed] [Google Scholar]

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