Fig. 3.

Approaches used for germline genomic data analysis. The approaches used for analysis of germline variation reported in the 160 included publications were tabulated. Targeted analysis of germline variants are solid bars. Genome-wide analysis of germline variants are striped bars. Articles used ‘known mutation status’ if the germline mutations were determined previously. ‘Other’ methods included methylation, karyotyping, or phenotype to assume genotype. Multiple approaches may have been used in a single article.