Histological assessment of colonic inflammation. (A) Score 0: no inflammation with normal crypt and goblet cells (arrow); m: mucosa; s: submucosa; ms: muscularis. H & E, 400×; (B) Score 1: minimal evidence of inflammatory infiltrate (arrow), H & E, 400×; (C) Score 2: significant evidence of inflammatory infiltrate (arrow), H & E, 400×; (D) Score 3: significant evidence of inflammatory infiltrate with goblet cell depletion (arrow), H & E, 400×; (E) Score 4: severe inflammation characterized by widespread infiltration with inflammatory cells, formation of crypt abscesses (arrows), mucosal thickening, submucosal cell infiltration, a decrease in goblet cells and destruction of architecture, H & E, 400×.