Continuous efforts are being made to develop new drugs or dietary supplements from natural products. These efforts are important in improving the outcomes of many intractable diseases.
In an article published in this issue of the International Neurourology Journal, the antiapoptotic effect of berberine against ischemic brain injury in gerbils has been reported [1]. The authors suggest that this antiapoptotic effect might be mediated through the inhibition of reactive astrogliosis and microglia activation.
Berberine is a type of isoquinoline alkaloid extracted from the root of Coptis japonica, the bark of Phellodendron amurense, and the root of Berberis vulgaris. Currently, the major clinical indications of berberine include bacterial diarrhea, intestinal parasite infections, and ocular trachoma infections. The diverse effects of berberine on tumors, diabetes mellitus, cardiovascular deregulation, immunology disorders, and neurodegenerative diseases have been studied [2,3,4,5].
Berberine has been shown to suppress the growth of bladder cancer and has been proposed as a novel chemotherapeutic agent [6]. Pretreatment with berberine elicited a protective effect against hypoxia/reoxygenation-induced apoptosis in human renal proximal tubular cells [7]. Berberine was suggested as a possible agent to improve neurogenic bladder in diabetic rats as well [8].
The effects of berberine on urological disorders have also been reported. Functional studies on the diverse mechanisms of berberine will be helpful for the treatment of stroke-associated neurourological diseases.
References
- 1.Kim M, Shin MS, Lee JM, Cho HS, Kim CJ, Kim YJ, et al. Inhibitory effects of isoquinoline alkaloids on ischemia-induced apoptosis via activation of phosphoinositide 3-kinase/protein kinase B signaling pathway. Int Neurourol J. 2014;18:115–125. doi: 10.5213/inj.2014.18.3.115. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Bhutada P, Mundhada Y, Bansod K, Tawari S, Patil S, Dixit P, et al. Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes. Behav Brain Res. 2011;220:30–41. doi: 10.1016/j.bbr.2011.01.022. [DOI] [PubMed] [Google Scholar]
- 3.Imanshahidi M, Hosseinzadeh H. Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother Res. 2008;22:999–1012. doi: 10.1002/ptr.2399. [DOI] [PubMed] [Google Scholar]
- 4.Wang F, Zhao G, Cheng L, Zhou HY, Fu LY, Yao WX. Effects of berberine on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus. Brain Res. 2004;999:91–97. doi: 10.1016/j.brainres.2003.11.036. [DOI] [PubMed] [Google Scholar]
- 5.Yoo KY, Hwang IK, Lim BO, Kang TC, Kim DW, Kim SM, et al. Berberry extract reduces neuronal damage and N-Methyl-D-aspartate receptor 1 immunoreactivity in the gerbil hippocampus after transient forebrain ischemia. Biol Pharm Bull. 2006;29:623–628. doi: 10.1248/bpb.29.623. [DOI] [PubMed] [Google Scholar]
- 6.Yan K, Zhang C, Feng J, Hou L, Yan L, Zhou Z, et al. Induction of G1 cell cycle arrest and apoptosis by berberine in bladder cancer cells. Eur J Pharmacol. 2011;661:1–7. doi: 10.1016/j.ejphar.2011.04.021. [DOI] [PubMed] [Google Scholar]
- 7.Yu W, Sheng M, Xu R, Yu J, Cui K, Tong J, et al. Berberine protects human renal proximal tubular cells from hypoxia/reoxygenation injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways. J Transl Med. 2013;11:24. doi: 10.1186/1479-5876-11-24. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.Ren LM, Zhuo YJ, Hao ZS, He HM, Lu HG, Zhao D. Berberine improves neurogenic contractile response of bladder detrusor muscle in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2013;150:1128–1136. doi: 10.1016/j.jep.2013.10.039. [DOI] [PubMed] [Google Scholar]