Table 1.

Association of seven transethnic SNPs with type 2 diabetes in longitudinally studied participants from the Gila River Indian Community

SNP	Locusa	Allelea(R/NR)	Longitudinally studied American Indians							Transethnic meta-analysis GWASa			Powerf (N = 7,710)
			RAF	T2Db (N = 7,710)		BMIc (N = 6,839)		T2D (adjmaxBMI)d (n = 6,587)		T2D
				OR (95% CI)a	p	β	p	OR (95% CI)	p	RAFa,e	OR (95% CI)	p
rs17106184	FAF1	G/A	0.992	1.29 (0.78, 2.14)	0.32	0.003	0.88	1.24 (0.75, 2.06)	0.4	0.58–0.95	1.10 (1.07, 1.14)	4.1 × 10−9	0.11
rs6808574	LPP	C/T	0.966	0.90 (0.67, 1.21)	0.49	−0.025	0.06	0.93 (0.68, 1.27)	0.63	0.60–0.98	1.07 (1.04, 1.09)	5.8 × 10−9	0.18
rs6813195	TMEM154	C/T	0.53	1.12 (1.03, 1.22)	0.01	−0.007	0.08	1.13 (1.03, 1.23)	0.007	0.39–0.71	1.08 (1.06, 1.10)	4.1 × 10−14	0.91
rs702634	ARL15	A/G	0.963	0.87 (0.67, 1.14)	0.31	−0.003	0.82	0.88 (0.66, 1.15)	0.35	0.67–0.86	1.06 (1.04, 1.09)	6.9 × 10−9	0.16
rs9505118	SSR1–RREB1	A/G	0.56	1.08 (0.99, 1.18)	0.08	0.001	0.78	1.08 (0.99, 1.18)	0.1	0.35–0.75	1.06 (1.04, 1.08)	1.4 × 10−9	0.71
rs3130501	POU5F1–TCF19	G/A	0.63	1.08 (0.99, 1.18)	0.08	−0.012	0.004	1.11 (1.02, 1.22)	0.02	0.43–0.76	1.07 (1.04, 1.09)	4.2 × 10−9	0.8
rs4275659	MPHOSPH9	C/T	0.47	0.99 (0.90, 1.08)	0.77	0.005	0.28	0.99 (0.91, 1.08)	0.82	0.53–0.78	1.06 (1.04, 1.08)	9.5 × 10−9	0.73

^aData derived from the genome-wide transethnic meta-analysis report [1]

^bT2D association was analysed in 3,625 full-heritage Pima Indians and 4,085 mixed-heritage American Indians who had some degree of American Indian heritage (on average a person’s heritage was two-thirds American Indian), the p value and OR (95% CI) were adjusted for age, sex, birth year, family membership and admixture estimates

^cMaximum recorded lifetime BMI (age ≥15 years) was used for the BMI association analysis, p values were adjusted for age, sex, birth year, family membership and admixture estimates, β coefficients represent the effect on a logarithmic scale per copy of the risk allele

^d p values and ORs (95% CI) for T2D association were also adjusted for maximum lifetime BMI (adjmaxBMI) in participants who were defined for both T2D and BMI

^eRAF ranges for the lead SNPs at the respective loci in Europeans, East Asians, South Asians, Mexicans and Mexican Americans

^fThe power of the current study to detect an effect size for T2D similar to the transethnic meta-analysis study calculated using the RAF and diabetes prevalence in American Indians

NR, non-risk allele; R, risk allele based on genome-wide transethnic meta-analysis [1], T2D, type 2 diabetes