TABLE 2.
MPL-Regulated probe sets related to cell signaling
| 230A probe set | 230A accession | U34A probe set/accession | Symbol | Identification | Response
|
|
|---|---|---|---|---|---|---|
| Acute | Chronic | |||||
| 1371081 | U78517 | U78517 | Cgef2, Rapgef4 | Rap guanine nucleotide exchange factor (GEF) 4 | Up | Up |
| 1367960 | NM_019186 | X77235 | Arl4 | ADP-ribosylation factor-like 4 | Up | Up |
| 1398790 | NM_017039 | AI012595 | Ppp2ca | Protein phosphatase 2a, catalytic sub-unit, α isoform | Up | Up |
| 1368147, 1368146 | U02553, BE110108 | U02553 | Ptpn16, Dusp1 | MAPK phosphatase-1, protein tyrosine phosphatase non-receptor-type 16 | Up | Up |
| 1387078 | NM_031002 | U26397 | Inpp4a | Inositol polyphosphate-4-phosphatase, type 1 | Up | Up |
| 1398847, 1370180 | AA891213, BG376935 | U95001 | Nudt4 | Diphosphoinositol polyphosphate phosphohydrolase 2 | Up | Up |
| 1377136, 1367697 | NM_031020, AW254190 | AA924542, U73142 (2), AI171630, U91847, AI137862 | Mapk14, p38 | MAPK 14 | Up | Up |
| 1367802 | NM_019232 | L01624 | Sgk | Serum/glucocorticoid-regulated kinase, serine/threonine protein kinase SGK | Up | Up |
| 1367725 | NM_022602 | AF086624 | Pim3 | Serine/threonine-protein kinase pim-3 | Up | Up |
| 1380262 | AA893436 | AA893436 | sgk | Serum/glucocorticoid regulated kinase | Up | Up |
| 1368947 | NM_024127 | L32591 (2), AI070295, AI070295 | Gadd45a | Growth arrest and DNA-damage-inducible 45α | Up | Up |
| 1369065 | NM_017290 | J04024 | Atp2a2, Serca2 | ATPase, Ca2+ transporting | Up | Up |
| 1387154 | NM_012614 | M15880 | Npy | Neuropeptide Y (Npy) | Up | Up |
| 1372558 | AI177404 | AI177404 | NMDA receptor-regulated gene 1 | Up | Up | |
| 1389974 | BF555171 | L15618 | CK2 | Casein kinase II α subunit | Up | Up |
| 1387907 | J05510 | J05510 | InsP3R1 I145TR |
Inositol 1,4,5-triphosphate receptor | Up | Up |
| 1373306 | BM386212 | M81639 | Snn | Stannin | Up | Up |
| 1372355 | BE109242 | U09793 | c-Ki-ras | Kirsten rat sarcoma viral oncogene homolog 2 | Up | Up |
| 1373082 | AA893743 | AA893743 | Protein kinase inhibitor, α | Up | Up/down | |
| 1372770 | BF281357 | X13933 | CaMI | Calmodulin 1 | Up | Down/up |
| 1390240 | BM389611 | AA800456 | CKLiK | Calcium-calmodulin-dependent kinase I-like kinase (CKLiK) | Down | Up |
| 1377417 | BE099931 | AA800678 | Ticam1 | Toll-like receptor adaptor molecule 1 | Down | Up |
| 1370522 | L04796 | M96674 | Gcgr | Glucagon receptor | Down | Up |
| 1387981 | AF079864 | AF079864 | Olfr78 | G-protein coupled receptor RA1c, olfactory receptor 59 | Down | Up |
| 1368675 | NM_032084 | AI232194 | CHN2 | Chimerin (chimaerin) 2 | Down | Up |
| 1368289 | AA944965 | M12450 | Vdbp, DBP02 | Group-specific component (vitamin D-binding protein) | Down | Up |
| 1390798 | BF288130 | M10072 | L-CA | Leukocyte common antigen | Down | Down |
| 1387024 | NM_053883 | X94185 | mkp-3 | MAPK phosphatase | Down | Down |
| 1368871 | NM_053887 | U48596 | Map3k1 | MAPK kinase kinase 1 | Down | Down |
| 1368646 | NM_017322 | L27112, AI231354 | Mapk9 | MAPK 9 | Down | Down |
| 1387024 | NM_053883 | X94185, U42627 | Dusp6 | Dual specificity phosphatase 6 | Down | Down |
| 1368646 | NM_017322 | AI231354 | SAPK | Stress-activated protein kinase α II | Down | Down |
| 1372844, 1398273 | AW531877, NM_053599 | AA892417, D38056 | Efna1, B61 | Eph-related receptor tyrosine kinase ligand 1 | Down | Down |
| 1389779 | AA800626 | AA800626 | Sh2d4a | SH2 domain containing 4A | Down | Down |
| 1375879 | BE111762 | AF061443 | Gpr48 | G protein-coupled receptor 48 | Down | Down |
| 1367644 | L01115 | L01115 | Adcy6 | Adenylyl cyclase type VI | Down | Down |
| 1369644 | NM_134408 | AF063102 | CIRL-2 | Calcium-independent α-latrotoxin receptor homolog 2, latrophilin 2 | Down | Down |
| 1368924 | NM_017094 | Z83757 (2) | Ghr | GH receptor | Down | Down |
| 1377966 | BI275560 | AA894316 | paqr7 | Progestin and adipoQ receptor family member VII | Down | Down |
| 1367745 | NM_031143 | D78588 | Dgkz | Diacylglycerol kinase ζ | Down | Down |
| 1371969 | BI291848 | AI180288 | Cald1 | Caldesmon 1 | Down | Down |
| 1368202 | NM_024159 | U95178 | Dab2 | Disabled homolog 2 | Up/down | Down |
| 1367881 | NM_013016 | D85183 | SHPS-1 | Protein tyrosine phosphatase, non-receptor-type substrate 1 | Up/down | Down |
| 1370949, 1370948, 1373432 | BE111604, M59859 | AA859896, AA925762, AA899253 | Macs | Myristoylated alanine-rich C-kinase substrate | Up | Down |
| 1368856 | NM_031514 | U13396, AJ000557, U13396 | Jak2 | Janus kinase 2 | Up | Down |
| 1368693 | NM_024145 | X57018 | Fgr | Gardner-Rasheed feline sarcoma viral oncogene homolog (kinase) | Up | Down |
| 1367844 | M12672 | AA875225 | G-α-i2 | GTP-binding protein | Up | Down |
| 1368975, 6, 1390325 | NM_013127, D30795, BI289418 | D29646 | Cd38 | ADP-ribosyl cyclase; CD38 | Up | Down |
| 1368821, 1368822, 1372331 | BG665037, BI290885, NM_024369 | AA891233 | Fstl1 | Follistatin-related protein | Up | Down |
| 1370288 | AF372216 | X02412, M60666 | TP-3 | Tropomyosin α-isoform | Up | Down |
| 1388140 | AW253722 | M83678 | Rab13 | RAB13, member RAS oncogene family | Down/up | Down |
| 1370414 | M94043 | M94043 | Rab38 | Rab38, member of RAS oncogene family | Down/up | Down |
| 1368821 | NM_024369 | AA859885, AA891233 | Frp, Fstl1 | Follistatin-like 1, activin-binding protein | Down/up | Down |
| 1368536 | NM_057104 | D28560 | NPH-type III | Phosphodiesterase I/nucleotide pyrophosphatase 2 | Down | Down/up/down |
Probe sets regulated by MPL in rat liver after both acute and chronic drug administration and categorized as relating to cell signaling. Affymetrix 230A arrays use a probe set number distinct from GenBank accession numbers, whereas U34A chips use a common probe set/GenBank accession number for identification.