Table 2.

Association of Novel AF Loci in the METASTROKE Consortium⁹

Phenotype	Cases	Controls	SNP	AF Risk Allele	Closest gene	RAF	OR (95% CI)	P
Overall ischemic stroke	12,389	62,004	rs12415501	T	NEURL	0.16	1.03 (0.99 – 1.08)	0.20
			rs10507248	T	TBX5	0.73	1.05 (1.01 – 1.08)	0.01
			rs4642101	G	CAND2	0.65	0.95 (0.93 – 0.99)	0.95
			rs13216675	T	GJA1	0.69	1.04 (1.01 – 1.08)	0.02
			rs6490029	A	CUX2	0.23	0.95 (0.91 – 0.98)	0.0034
Cardioembolic stroke	2,365	56,140	rs12415501	T	NEURL	0.16	1.10 (1.01 – 1.20)	0.03
			rs10507248	T	TBX5	0.73	1.11 (1.04 – 1.19)	0.0027
			rs4642101	G	CAND2	0.65	1.04 (0.97 – 1.11)	0.23
			rs13216675	T	GJA1	0.69	1.13 (1.05 – 1.21)	0.0013
			rs6490029	A	CUX2	0.23	0.98 (0.91 – 1.05)	0.55