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. Author manuscript; available in PMC: 2015 Oct 7.
Published in final edited form as: Structure. 2014 Sep 18;22(10):1520–1527. doi: 10.1016/j.str.2014.08.009

Figure 1. Membrane topology of mouse PIEZO1 as predicted by various membrane topology prediction algorithms.

Figure 1

Depending on the membrane topology prediction algorithm, mouse PIEZO1 is predicted to have 30 to 40 transmembrane segments. The numbers of amino acids (aa) for the larger predicted loops are indicated. The loop of interest, CTL2 (red box), is predicted to be extracellular by 3 of the 4 topology prediction algorithms. Since mouse PIEZO1 is the most extensively characterized Piezo channel, it is used to illustrate the topology predictions; Diagrams are drawn using TOPO2 (Johns) http://www.sacs.ucsf.edu/TOPO2/). See also Figure S1.