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. 1972 Dec;6(6):905–908. doi: 10.1128/iai.6.6.905-908.1972

Lymphocyte Transformation in Chagas Disease

E Irene Tschudi a, Dante F Anziano a, Agustin P Dalmasso a,1
PMCID: PMC419310  PMID: 4629392

Abstract

The in vitro response of human peripheral lymphocytes to Trypanosoma (Schizotrypanum) cruzi antigens and to phytohemagglutinin was used to study the role of cellular immunity in Chagas disease (American trypanosomiasis). Solubilized T. cruzi antigens elicited 5 to 30% transformed cells in 5-day cultures of lymphocytes from adults chronically infected with T. cruzi. No major difference was noted between the response of 22 asymptomatic individuals and of 3 patients with chagasic cardiopathy. No correlation was found between degree of lymphocytic transformation and serum antibody titer. Lymphocytes from 15 normal controls yielded no significant transformation. Intradermal tests provoked a local delayed hypersensitivity reaction in infected individuals only, as evaluated clinically and histologically. The response to phytohemagglutinin of lymphocytes from chronically infected individuals was identical with that of normal controls.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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