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. 2014 Oct 7;2:e614. doi: 10.7717/peerj.614

Figure 1. Effect of PAP-1 on glucose uptake in soleus muscles of male (A) wild-type and (B) ob/ob C57Bl6 mice.

Figure 1

Muscles were treated with insulin (wild-type, 10 nM; ob/ob, 100 nM) or PAP-1 (3 µM) alone, or the combination of insulin and PAP-1. n = 8 mice per group for all columns. Data for each genotype were analyzed by one-way ANOVA followed by Fisher’s least significant difference test. ∗ P < 0.05; ∗∗∗ P < 0.001 for effect of PAP-1 compared to controls (Con). †P < 0.05; †††P < 0.001 for effect of insulin (Ins) compared to controls. ‡‡‡P < 0.001 for the effect of the combination of PAP-1 and insulin compared to the absence of both compounds (Con). Note that in both wild-type and ob/ob mice, glucose uptake in the presence of the combination of PAP-1 and insulin was not significantly greater than in the absence of one of the compounds.