Correction: Trop-2 Is a Determinant of Breast Cancer Survival

There is an error in the third sentence of the second paragraph of the “Statistical Analysis” subsection of the Materials and Methods. The correct sentence is: The CI curves were estimated using the 1-Kaplan-Meier probability plots.

There are a number of errors in the headings for Table 2. Please see the corrected Table 2 here.

Table 2. Proportional hazard Cox regression analysis.

	Hazard ratio
	Death		Relapse a
	Unadjusted	Adjusted	Unadjusted	Adjusted
Membrane Trop-2
1+ versus 0	1.50 (0.04)	1.63 (0.04)	1.22 (0.30)	1.17 (0.49)
2+ versus 0	1.17 (0.47)	0.99 (0.97)	0.92 (0.68)	0.80 (0.38)
3+ versus 0	1.46 (0.12)	1.19 (0.58)	0.85 (0.55)	0.90 (0.74)
123+ versus 0	1.37 (0.08)	1.30 (0.23)	1.04 (0.82)	0.98 (0.93)
intermediate versus low	1.23 (0.19)	1.13 (0.52)	0.88 (0.40)	0.88 (0.50)
high versus low	1.16 (0.58)	1.45 (0.24)	0.67 (0.18)	0.80 (0.51)
Intracellular Trop-2 (mAb)
1+ versus 0	0.91 (0.62)	0.80 (0.32)	0.93 (0.69)	0.82 (0.37)
2+ versus 0	0.73 (0.17)	0.55 (0.03)	0.70 (0.11)	0.53 (0.02)
3+ versus 0	0.95 (0.80)	0.70 (0.18)	0.72 (0.15)	0.56 (0.03)
123+ versus 0	0.87 (0.39)	0.69 (0.05)	0.81 (0.18)	0.67 (0.04)
intermediate versus low	0.99 (0.93)	0.91 (0.66)	0.87 (0.44)	0.85 (0.42)
high versus low	0.75 (0.15)	0.48 (0.003)	0.75 (0.14)	0.51 (0.004)
Intracellular Trop-2 (pAb)
1+ versus 0	0.80 (0.27)	1.16 (0.56)	0.78 (0.25)	0.98 (0.93)
2+ versus 0	0.59 (0.004)	0.59 (0.03)	0.79 (0.20)	0.76 (0.24)
3+ versus 0	0.81 (0.50)	0.88 (0.75)	0.84 (0.59)	0.82 (0.67)
123+ versus 0	0.67 (0.02)	0. 70 (0.08)	0.79 (0.17)	0.77 (0.21)
intermediate versus low	0.72 (0.07)	0.76 (0.21)	0.90 (0.59)	0.85 (0.46)
high versus low	0.62 (0.02)	0.55 (0.02)	0.77 (0.20)	0.73 (0.20)

Unadjusted and adjusted hazard ratios according to Trop-2 expression levels (at the cell membrane or intracellular, as detected by mAb or pAb) and corresponding P values.

^a: cause-specific hazard ratios. The adjusted models included age (continuous linear), grading, pT stage (pT2+pT3 versus pT1), number of positive lymph nodes (0, 1-3, 4-9, >9), ERα, HER-2/neu, p53 and E-cadherin (cut-off: 10% positive cells). Low; ≤ 5% positive cells; intermediate, 6-85%; high, ≥ 86%. Significantly different values and trends are in bold.

There is an error in the legend for Figure 4. Please see the corrected Figure 4 here.

Figure 4. Impact of membrane versus intracellular Trop-2 on patient survival.

Cumulative incidence (CI) estimates of death from any cause are reported on the y-axis as a function of follow-up time for distinct Trop-2 expression sub-groups (cell membrane; mAb-detected intracellular; pAb-detected intracellular). Trop-2 expression was categorized according to (top) intensity scores (0, 1+, 2+, 3+), (middle) intensity grouping, i.e. positive scores 1–12 (+) versus score 0 (−), (bottom) percentage of stained cells (low, ≤5%; intermediate, 6–85%; high, ≥86%), as indicated in the panels.

There is an error in the legend for Figure 5. Please see the corrected Figure 5 here.

Figure 5. Impact of membrane versus intracellular Trop-2 on disease relapse.

Crude cumulative incidence (CCI) estimates of disease relapse are reported on the y-axis as a function of follow-up time for distinct Trop-2 expression sub-groups (cell membrane; mAb-detected intracellular; pAb-detected intracellular). Trop-2 expression was categorized according to (top) intensity scores (0, 1+, 2+, 3+), (middle) intensity grouping, i.e. positive scores 1–12 (+) versus score 0 (−), (bottom) percentage of stained cells (low, ≤5%; intermediate, 6–85%; high, ≥86%), as indicated in the panels. CCI were estimated accounting for death as a competing risk.