Table 1.

Baseline lung function data comparing obese non-asthmatics, obese asthmatics with elevated serum IgE (T_H2-high) and obese asthmatics with normal serum IgE (T_H2-low)

	Obese Non- Asthmatic	Obese Asthma		p- value
		TH2-high	TH2-low
IgE (IU/mL)*	-	282 [175 – 546]	20 [1 – 49]	-
N (female)	8 (8)	10 (9)	12 (11)	-
Age (years)	41.1 ± 7.4	42.1 ± 8.7	44.6 ± 10.7	0.72
BMI (kg/m2)*	48.6 [42.7 – 57.6]	47.8 [43.3 – 58.7]	46.7 [42.3 – 50.5]	0.85
FEV1 (% pred)	87.8 ± 9.7	83.2 ± 8.6	80.6 ± 6.9	0.40
FVC (% pred)	91.1 ± 10.4	87.7 ± 8.3	83.1 ± 7.7	0.34
FEV1/FVC	77.5 ± 5.1	77.5 ± 5.6	78.8 ± 2.2	0.83
PEF (% pred)*	86.1 [76.5 – 90.4]	89.4 [78.3 – 108.2]	91.7 [80.7 – 97.1]	0.45
Rrs 5Hz (cmH2O/L/s) $	7.0 ± 3.2	7.3 ± 2.2	7.3 ± 1.1	0.97
Rrs 20Hz (cmH2O/L/s)$	5.1 ± 1.1	5.3 ± 1.6	5.1 ± 0.7	0.95
Rrs 5Hz–20Hz (cmH2O/L/s)$	2.0 ± 1.9	2.0 ± 1.2	2.1 ± 0.7	0.97
Xrs 5Hz (cmH2O/L/s)*$	−2.2 [−3.3 – −1.7]	−2.2 [−4.9 – −1.8]	−2.7 [−4.0 –−2.0]	0.83
Max fall in FEV1	15.9 ± 2.9	22.2 ± 3.6A	25.1 ± 3.8A	0.002
DRS (% fall FEV1/µmol MCh)#	3.8 [3.0 – 4.7]	18.0 [7.4 – 43.4]A	24.5 [13.9 – 43.3]A	0.005
AHR (n)^	2	8	12
Closing Index	0.71 ± 0.07	0.71 ± 0.12	0.79 ± 0.07	0.26

All data are presented as mean ± 95% CI unless otherwise stated.

^*Median [IQR],

^#geometric mean ± 95 % CI

^$Data are from 5 non-asthmatic subjects

^{^}number of subjects with AHR as defined by PC₂₀FEV₁ < 16mg/mL

^Ap-value < 0.05 vs obese non-asthmatic

FEV₁ = forced expiratory volume in one second, FVC = forced expiratory volume, PEF = peak expiratory flow, Rrs = respiratory system resistance, Xrs = respiratory system reactance, DRS = dose response slope, MCh = methacholine, AHR = airway hyperresponsiveness, defined as >4.4% fall FEV₁/µmol MCh, N= number.