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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Respirology. 2014 Aug 19;19(8):1170–1177. doi: 10.1111/resp.12368

Table 2.

Comparison of changes in baseline lung function for obese asthmatic subjects prior to bariatric surgery and 12 months following bariatric surgery stratified by IgE levels prior to surgery

TH2-high (n = 5) TH2-low (n = 8)
Pre-surgery Post-surgery Pre-post
change		 Pre-surgery Post-surgery Pre-post
change		 Weight
loss
p-value		 interaction
p-value
BMI (kg/m2) 50.9 ± 13.7 32.4 ± 13.1 18.4 ± 6.3 50.7 ± 9.3 38.7 ± 6.3 11.9 ± 5.0 < 0.0001 0.07
FEV1 (% pred) 86.2 ± 10.1 97.0 ± 8.1 −10.8 ± 7.6 80.1 ± 9.0 91.2 ± 6.7 −11.8 ± 4.6 < 0.0001 0.86
FVC (% pred) 89.2 ± 4.4 99.8 ± 9.2 −10.6 ± 12.7 82.1 ± 9.9 91.0 ± 10.2 −8.9 ± 4.9 0.001 0.70
FEV1/FVC 79.2 ± 9.8 79.6 ± 9.6 −0.4 ± 5.5 79.0 ± 2.8 80.6 ± 3.1 −1.5 ± 2.2 0.35 0.58
PEF (% pred) 91.2 [79.3 – 105.0] 85.4 [79.5 – 104.3] −3.4 [−15.0 – 20.1] 94.7 [86.7 – 99.2] 103.1 [90.3 – 114.6] −10.2 [−22.2 – 0.1] 0.28 0.17
Rrs 5Hz (cmH2O/L/s) 7.0 ± 3.5 4.4 ± 1.7 2.6 ± 1.8 7.2 ± 1.4 7.0 ± 1.9 0.3 ± 2.3 0.05 0.11
Rrs 20Hz (cmH2O/L/s)* 5.3 [4.6 – 7.7] 3.9 [3.2 – 4.9] 1.5 [1.3 – 2.8] 5.4 [4.4 – 6.6] 4.9 [4.4 – 6.1] 0.6 [−1.8 – 0.8] 0.05 0.03
Rrs 5Hz–20Hz (cmH20/L/s)* 0.84 [0.3 – 1.9] 0.21 [0.06 – 0.9] 0.85 [0.16 – 1.05] 1.9 [1.1 – 3.0] 1.1 [0.7 – 2.5] 0.05 [−0.8 – 2.0] 0.14 0.73
Xrs 5Hz (cmH2O/L/s)* −2.1 [−4.2 – −1.5] −1.2 [−1.6 – −0.9] −0.9 [−3.0 –−0.3] −2.4 [−3.6 – −2.0] −1.4 [−1.8 – −1.1] −0.6 [−1.9 –−0.2] 0.01 0.44
Max % fall in FEV1 22.7 [21.3 – 27.4] 22.7 [21.3 – 41.6] −0.3 [−19.4 – 5.3] 23.0 [21.7 – 29.2] 21.5 [14.1 – 27.4] 4.4 [−1.3 – 10.5] 0.79 0.16
Closing Index 0.72 ± 0.16 0.65 ± 0.14 0.07 ± 0.26 0.79 ± 0.1 0.65 ± 0.17 0.14 ± 0.09 0.03 0.47
DRSFEV1 (% fall /µmol MCh)$ 36.8 [7.3 – 186.4] 49.2 [21.7 – 111.4] −0.4 ± 1.8^ 31.1 [14.9 – 65.0] 11.7 [5.2 – 26.2] 1.4 ± 0.9 0.29 0.07
DRS(FEV1/FVC) (% fall /µmol MCh)$ 9.9 [1.1 – 86.6] 20.8 [10.5 – 41.4] −1.1 ± 2.5^ 6.0 [2.1 – 17.0] 1.7 [1.2 – 10.2] 0.8 ± 1.0^ 0.79 0.15
logDRS FVC (% fall/µmol MCh)$ 26.4 [5.6 – 123.7] 31.6 [12.4 – 31.6] −0.3 ± 1.7^ 24.3 [11.1 – 53.2] 7.4 [3.0 – 17.6] 1.8 ± 0.8^ 0.11 0.04

Data were analysed only from those subjects in whom methacholine challenge caused a > 5% fall in FEV1 at both study visits.

All data are presented as mean ±95% CI unless otherwise stated.

P-values shown are from mixed model repeat measures analysis of variance. Interaction designates the TH2-group × surgery interaction factor.

*

Median [IQR],

$

geometric mean ± 95 % CI,

^

doubling doses

#

n = 5 for high IgE and 7 for low IgE

FEV1 = forced expiratory volume in one second, FVC = forced expiratory volume, PEF = peak expiratory flow, Rrs = respiratory system resistance, Xrs = respiratory system reactance, DRS = dose response slope, MCh = methacholine. The Closing Index, calculated as the % fall in FVC/ % fall in FEV1 at the highest dose of the methacholine challenge, with larger numbers represen