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. 2014 Jun;14(2):494. doi: 10.4314/ahs.v14i2.33

GeneXpert in the diagnosis of smear-negative PTB

Beuy Joob 1, Viroj Wiwanitkit 2
PMCID: PMC4196400  PMID: 25320607

Sir, the recent report on “GeneXpert in the diagnosis of smear-negative PTB” is very interesting [1]. As Nakiyingi et al. noted, the concern on cost effectiveness on this new TB diagnostic tool is needed [1]. In fact, the cost effectiveness of the test is still controversial issue [2]. The value seems dependent to the setting [23]. Also, Nakiyingi et al. raised an important point that GeneXpert can help fasten diagnosis. However, it is questionable whether we actually need such a very fast result. The GeneXpert might not add any important clinical usefulness to the use of classical culture.

References

  • 1.Nakiyingi L, Nankabirwa H, Lamorde M. Tuberculosis diagnosis in resource-limited settings: Clinical use of GeneXpert in the diagnosis of smear-negative PTB: a case report. Afr Health Sci. 2013 Jun;13(2):522–524. doi: 10.4314/ahs.v13i2.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Muñoz L, Moure R, Porta N, Gonzalez L, Guerra R, Alcaide F, Santin M. GeneXpert® for smear-negative pulmonary tuberculosis: does it play a role in low-burden countries? Diagn Microbiol Infect Dis. 2013 Mar;75(3):325–326. doi: 10.1016/j.diagmicrobio.2012.11.011. [DOI] [PubMed] [Google Scholar]
  • 3.Dowdy DW, Cattamanchi A, Steingart KR, Pai M. Is scale-up worth it? Challenges in economic analysis of diagnostic tests for tuberculosis. PLoS Med. 2011 Jul;8(7):e1001063. doi: 10.1371/journal.pmed.1001063. [DOI] [PMC free article] [PubMed] [Google Scholar]

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