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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Immunotherapy. 2014;6(6):755–774. doi: 10.2217/imt.14.37

Figure 3. Hot spot in CD2-CD58 structure used for the design of CD2-based peptides for immunomodulation.

Figure 3

Tyr86 and Phe46 sandwich the Lys34 forming a hydrophobic interaction. Mutation of Tyr86 by Ala results in complete loss of binding of CD2 protein to CD58 suggesting hot-spot residues in the interaction of CD2 and CD58 [44].